98687-97-9

Upstream product

• 111322-63-5 (R)-(-)-(2-Hydroxy-1-naphthyl)methylphenylphosphine oxide 
• 74-88-4 methyl iodide 
• 160722-05-4 (+/-)-(2-Acetoxy-1-naphthyl)methylphenylphosphine oxide 
• 111282-85-0 (+/-)-(2-Hydroxy-1-naphthyl)methylphenylphosphine oxide 

Relevant academic research and scientific papers

METHOD FOR INCREASING THE ENANTIOMERIC EXCESS OF CHIRAL PHOSPHINE OXIDES, SULPHIDES, IMIDES AND BORANES

The present invention relates to a method for increasing the enantiomeric excess of a chiral phosphine oxide, a chiral phosphine sulphide, a chiral phosphine-borane and a chiral phosphine imide said method comprising the steps of: (a) contacting said chiral phosphine oxide, sulphide, imide or borane with a solvent to form a slurry; (b) partitioning the phosphine oxide, sulphide, imide or borane either into the solvent or as an insoluble product; and (c) optionally, isolating the partitioned phosphine oxide, sulphide, imide or borane.

Kinetic Resolution of Phosphines and Phosphine Oxides with Phosphorus Stereocenters by Hydrolases

Lipase from Candida rugosa (CRL) and cholesterol esterase (CE) catalyzed the enantioselective hydrolysis of pendant acetates in chiral phosphines and phosphine oxides.The enantioselectivity for most substrates was modest (E= 1.5-4.8), but both hydrolases