98698-57-8Relevant academic research and scientific papers
ALDOL CONDENSATIONS OF ETHYL 1,3-DITHIOLANE-2-CARBOXYLATE AND ETHYL 1,3-DITHIANE-2-CARBOXYLATE WITH CHIRAL ALDEHYDES. EXCEPTIONAL DIASTEREOFACE SELECTIVITY FROM TWO CONVENIENT ACETATE EQUIVALENTS.
Flippin, Lee A.,Dombroski, Mark A.
, p. 2977 - 2980 (1985)
Lithium enolates derived from the title esters show high diastereoface selectivity in their reactions with chiral aldehydes.The resulting 2,2-dithioaldols are desulfurized in good yield with Ni2B-H2 (EtOH, 20 deg C).With this mild desulfurization protocol, complete retention of stereochemical integrity was observed for all isolated aldols.
