98700-52-8

Basic information

• Product Name: 1H-Pyrazole-4-carboxaldehyde, 1,5-diphenyl-
• CAS NO: 98700-52-8
• Molecular Formula: C16H12N2O
• Molecular Weight: 248.284
• Mol File: 98700-52-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxaldehyde, 1,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxaldehyde, 1,5-diphenyl-(98700-52-8)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxaldehyde, 1,5-diphenyl-(98700-52-8)

Safety Data

• Hazardous Substances Data: 98700-52-8(Hazardous Substances Data)

Upstream product

• 153863-42-4 (1,5-Diphenyl-1H-pyrazol-4-yl)-methanol 
• 98700-51-7 4-(4-Fluorophenylimino)methyl-1,5-diphenyl-1H-pyrazole 
• 98700-38-0 4-[3-(4-Fluoro-phenyl)-5-methylene-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine 
• 3815-83-6 3,4-diphenylsydnone 

Downstream Products

• 296269-51-7 4-dimethylamino-1-(1,5-diphenyl-1H-pyrazol-4-yl)-butan-1-ol 
• 193747-23-8 (1,5-Diphenyl-1H-pyrazol-4-yl)-phenyl-methanol 

Relevant articles and documents

ω-Dialkylaminoalkyl Ethers of Phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with Analgesic and Anti-inflammatory Activity

A series of carbinols 3a-f was prepared starting from methanols 1a-f via oxidation with pyridinium chlorochromate to aldehydes 2a-f, followed by a Grignard reaction of the latter. Reaction of 3a-f with ω-chloroalkyldialkylamine hydrochlorides afforded a series of aminoether derivatives 4g-t. Compounds 4i,m-p,s showed a good analgesic activity in the acetic acid writhing test in mice. Moreover, compounds 4h,l,s exhibited a moderate anti-inflammatory activity in the carrageenan-induced edema assay in rats.