98704-22-4Relevant academic research and scientific papers
Maleimidophenyl isocyanates as postpolymerization modification agents and their applications in the synthesis of block copolymers
Takashima, Rikito,Kida, Jumpei,Aoki, Daisuke,Otsuka, Hideyuki
, p. 2396 - 2406 (2019/08/07)
The maleimide structure is highly reactive, exemplified by thiol–ene click reactions with thiols and Diels–Alder reactions with furans. Although postpolymerization modifications and macromolecular conjugations involving maleimide units have been widely studied, mostly due to their selectivity and high reactivity, little has been reported on the one-pot postpolymerization introduction of maleimides in polymer chains. Herein, we report p-maleimidophenyl isocyanate and its derivatives as modification agents to introduce maleimide moieties by reaction with hydroxy groups into polymer chains. The high reactivity of the resulting modification agents and of the corresponding maleimide structures once inserted in the polymer chains was examined by studying their reaction kinetics. Furthermore, these modification agents were successfully applied to the synthesis of macromonomers for graft polymerization and various block copolymers, with, for example, AB-type, star-shaped, and H-shaped architectures.
Synthesis of a new highly sensitive near-infrared fluorescent iridium(III) probe and its application for the highly selective detection of glutathione
Chen, Hailang,Bao, Xiaofeng,Li, Feng,Zhou, Baojing,Ye, Renlong,Zhu, Jing
, p. 85095 - 85104 (2015/10/28)
A new near-infrared fluorescent probe 1 based on the IR 780 skeleton was designed, synthesized and structurally characterized for the development of a chemosensor. UV-vis absorption and fluorescence spectroscopic studies show that probe 1 exhibits a high
Convergent preparation and photophysical characterization of dimaleimide dansyl fluorogens: Elucidation of the maleimide fluorescence quenching mechanism
Guy, Julia,Caron, Karine,Dufresne, Stephane,Michnick, Stephen W.,Skene,Keillor, Jeffrey W.
, p. 11969 - 11977 (2008/03/13)
Dimaleimide fluorogens are being developed for application to fluorescent protein labeling. In this method, fluorophores bearing two maleimide quenching groups do not fluoresce until both maleimide groups have undergone thiol addition reactions with the C
1H and 13C NMR spectra for a series of arylmaleamic acids, arylmaleimides, arylsuccinamic acids and arylsuccinimides
Trujillo-Ferrara, Jose,Santillan, Rosa,Beltran, Hiram I.,Farfan, Norberto,Hoepfl, Herbert
, p. 682 - 686 (2007/10/03)
The 1H and 13C NMR spectra of 17 succinic anhydride derivatives and 25 maleic anhydride derivatives were completely assigned using one- and two-dimensional NMR techniques. Copyright
Design and synthesis of trifunctional perfluorophenyl azide-based photoactivatable reagents
Cai, Sui Xiong,Keana, John F. W.
, p. 809 - 818 (2007/10/03)
The novel trifunctional perfluorophenyl azide based photoactive compounds 3, 6 (unstable), 10 and 13 are described. Diels-Alder reaction of maleimide 13 with diene-heteropolytungstate 14 produced the PFPA-HPT-maleimide trifunctional conjugate 15.
Functionalized Keggin- and Dawson-Type Cyclopentadienyltitanium Heteropolytungstate Anions: Small, Individually Distinguishable Labels for Conventional Transmission Elactron Microscopy. 2. Reactions
Keana, John F. W.,Ogan, Marc D.,Lue, YiXin,Beer, Michael,Varkey, J.
, p. 7957 - 7963 (2007/10/02)
Our goal is to develop a series of small, highly electron dense reagents to label substrate molecules covalently and chemoselectively for subsequent visualisation by using conventional transmission electron microscopy (CTEM).Starting with the organic functionalized cyclopentadienyltitanium (CpTi) substituted Keggin- and Dawson-type heteropolytungstate (HPT) anions prepared in the accompanying paper, it was first established that the HPT unit as well as the Cp-Ti bond in those anions are stable under a variety of reaction conditions that lead to modification (esterification, acylation, reduction, reductive amination, oxidation, and cycloaddition reactions) of the organic appendage.A Diels-Alder reaction between either Keggin HPT diene 34 or Dawson HPT diene 18 and one of several substituted N-phenylmaleimides (27-33) was a versatile method for the attachment of a variety of protein-reactive groups to the HPT anions.Thus prepared were HPT maleimides 20 and 35, bromoacetamides 21 and 36, biotin derivative 22, isothiocyanate 24, and N-hydroxysuccinimide esters 37 and 40.Additionally, the new heterobifunctional dienophiles 29, 30, 32 and 33 should act as protein cross-linking agents, complementing those already available.Acylating agent 40 is noteworthy in that two Dawson HPT units are tethered in close proximity to each other in this reagent.By analogy to the EM image of "dimeric" HPT 23, the EM image of 40 is expected to be recognizable morphologically as dumbells.HPT-labeled ATP derivative 42 was prepared by a reductive amination of Dawson benzaldehyde 10 with N6-methyl>ATP (Li salt).Both Keggin and Dawson HPTs are visible individually by using CTEM.Their stability in the electron beam is high.
