98734-33-9Relevant academic research and scientific papers
4-Chloromercurioandrosta-4,6-diene-3,17-dione: Preparation, X-Ray Structure Determination, and Potential Utility
Drew, Michael G. B.,Mann, John,Pietrzak, Barbara
, p. 1049 - 1054 (2007/10/02)
The novel steroid 4-chloromercurioandrosta-4,6-diene-3,17-dione (2) was obtained as a major side-product during conversions of 6β-bromoandrost-4-ene-3,17-dione (1b) into its 6β-fluoro derivative (1a) using HF(pyridine)n and mercuric oxide.Compound (2) was successfully converted into various 4-substituted steroids (using standard vinyl-mercury methodology), including the disteroidal mercury compound (3c).Crystals of the acetone solvate of (2), 2(HgClC19H40O2)*acetone, were monoclinic, space group P21, Z=2 with dimensions a=7.295(8), b=24.12(1), c=12.215(12) Angstroem, β=108.0(1) deg.The two independent molecules have equivalent structures with the mercury atoms strongly bound to a chlorine atom and to carbon atom C(4) of the steroid.The acetone molecule forms a weak bridge between the two mercury atoms.
