Welcome to LookChem.com Sign In|Join Free

CAS

  • or

98735-75-2

Post Buying Request

98735-75-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

98735-75-2 Usage

General Description

2,5-Piperazinedione,3,3,6-trimethyl-,(S)-(9CI) is a chemical compound with the molecular formula C8H14N2O2. It is also known as (S)-3,3,6-trimethyl-2,5-diketopiperazine. 2,5-Piperazinedione,3,3,6-trimethyl-,(S)-(9CI) is a diketopiperazine derivative, which is commonly found in a variety of natural products and pharmaceuticals. It has been studied for its potential as a therapeutic agent, particularly in the field of anti-cancer research. Additionally, (S)-3,3,6-trimethyl-2,5-diketopiperazine has shown potential as a chiral auxiliary in asymmetric synthesis, making it a versatile compound with various potential applications in the pharmaceutical and chemical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 98735-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,3 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 98735-75:
(7*9)+(6*8)+(5*7)+(4*3)+(3*5)+(2*7)+(1*5)=192
192 % 10 = 2
So 98735-75-2 is a valid CAS Registry Number.

98735-75-2Downstream Products

98735-75-2Relevant articles and documents

Investigation of permeation of theophylline through skin using selected piperazine-2,5-diones

Pokorna, Aneta,Bobal, Pavel,Oravec, Michal,Rarova, Lucie,Bobalova, Janette,Jampilek, Josef

, (2019/02/26)

Transdermal administration of drugs that penetrate, in this case directly into the blood circulation, has many advantages and is promising for many drugs thanks to its easy application and good patient compliance. (S)-8-Methyl-6,9-diazaspiro[4.5]decan-7,10-dione (alaptide), has been studied as a potential chemical permeation enhancer. Based on its structure, four selected piperazine-2,5-diones were synthesized by means of multi-step synthetic pathways. All the compounds were investigated on their ability to enhance the permeation of the model drug theophylline from the hydrophilic medium propylene glycol:water (1:1). In vitro experiments were performed using vertical Franz diffusion cells at constant temperature 34 ± 0.5 ?C and using full-thickness pig (Sus scrofa f. domestica) ear skin. Withdrawn samples were analyzed by RP-HPLC for determination of the permeated amount of theophylline. All the compounds were applied in ratio 1:10 (w/w) relative to the amount of theophylline. One hour after application, the permeated amount of theophylline from formulations with alaptide and (3S,6S)-3,6-dimethylpiperazine-2,5-dione, was ca. 15- and 12-fold higher, respectively, than from the formulation without the tested compounds. Despite the enhancement ratio of both enhancers in a steady state was ca. 2.3, the pseudo-enhancement ratio in the time range from 1 to 3 h was 4.4. These enhancement ratios indicate that the compounds are able to enhance the permeation of agents through the skin; however, the short-term application of both compound formulations seems to be more advantageous. In addition, the screening of the cytotoxicity of all the prepared compounds was performed using three cell lines, and the compounds did not show any significant toxic effect.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 98735-75-2