98735-78-5Relevant articles and documents
IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROY2.5¨OCTANE RING STRUCTURE
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Page/Page column 96-97, (2011/04/18)
There is provided a novel compound that inhibits the interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits the interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R1 R2, R3, R4, R5, Ar1, and Ar2 in formula (1) each have the same meanings as defined in the specification.
Stereochemistry of Cyclic Dipeptides. Assignment of the Prochiral Methylenes of 1-Aminocyclopropane-1-carboxylic Acid
Woodard, Ronald W.
, p. 4796 - 4799 (2007/10/02)
The two enantiomeric methylene carbons of 1-aminocyclopropane-1-carboxylic acid (ACC) were differentiated by an NMR study.Several amino acids such as L-alanine, D-alanine, and 2-aminoisobutyric acid as well as ACC were condensed with L- and/or D-phenylala