98768-24-2Relevant academic research and scientific papers
STANNOUS TRIFLATE MEDIATED ALDOL REACTION OF 3-(3-ALKOXY AND 3-AMINOPROPANOYL)THIAZOLIDINE-2-THIONES STEREOSELECTIVE SYNTHESIS OF β-LACTAM DERIVATIVES
Iwasawa, Nobuharu,Huang, Huamin,Mukaiyama, Teruaki
, p. 1045 - 1048 (2007/10/02)
The tin(II) enolate is generated from 3-acylthiazolidine-2-thione with β-alkoxy or β-amino functionality on treatment with stannous triflate in the presence of N-ethylpiperidine.The enolate further reacts with aldehyde to afford the aldol product with high syn-stereoselectivity.The aldol product thus produced is stereospecifically converted to β-lactam derivative with hydroxyethyl side chain.
