98813-63-9Relevant academic research and scientific papers
Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2
Shahinshavali, Shaik,Hossain, Kazi Amirul,Kumar, Abbaraju Venkata Durga Nagendra,Reddy, Alugubelli Gopi,Kolli, Deepti,Nakhi, Ali,Rao, Mandava Venkata Basaveswara,Pal, Manojit
, (2020)
In view of recent global pandemic the 3-alkynyl substituted 2-chloroquinoxaline framework has been explored as a potential template for the design of molecules targeting COVID-19. Initial in silico studies of representative compounds to assess their bindi
Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest
Nakhi, Ali,Rahman, Md. Shafiqur,Seerapu, Guru Pavan Kumar,Banote, Rakesh Kumar,Kumar, Kummari Lalith,Kulkarni, Pushkar,Haldar, Devyani,Pal, Manojit
supporting information, p. 4930 - 4934 (2013/08/23)
A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.
Preparation and Reactions of 2-Alkynyl-3-chloroquinoxalines.
Ames, Donald E.,Mitchell, John C.,Takundwa, Chisango C.
, p. 1683 - 1696 (2007/10/02)
2-Alkynyl-3-chloroquinoxalines are prepared from 2,3-dichloroqionoxaline and alk-1-ynes: use of 2-methylbut-3-yn-2-ol, and the removal of acetone with base, yields 2-chloro-3-ethynylqionoxaline.The chloroalkynes are readily converted into pyrrolo- and thi
