98879-86-8

Upstream product

• 2625-21-0 1,3,6-trimethyl-1H,8H-pteridine-2,4,7-trione 
• 99073-12-8 (1,3-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pteridin-6-yl)-acetic acid 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 104912-17-6 (1,3-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pteridin-6-yl)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Immunosuppressive effects of pteridine derivatives

Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, being represented by the general formula (I). are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

Immunosuppressive effects of pteridine derivatives

Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts