98886-07-8Relevant academic research and scientific papers
Antibacterial activity of 3,3′-dihydroxycurcumin (DHC) is associated with membrane perturbation
Polaquini, Carlos R.,Mor?o, Luana G.,Nazaré, Ana C.,Torrezan, Guilherme S.,Dilarri, Guilherme,Cavalca, Lúcia B.,Campos, Débora L.,Silva, Isabel C.,Pereira, Jessé A.,Scheffers, Dirk-Jan,Duque, Cristiane,Pavan, Fernando R.,Ferreira, Henrique,Regasini, Luis O.
, (2019)
Curcumin is a plant diphenylheptanoid and has been investigated for its antibacterial activity. However, the therapeutic uses of this compound are limited due to its chemical instability. In this work, we evaluated the antimicrobial activity of diphenylhe
Method for artificially synthesizing curcumin and derivative thereof
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Paragraph 0055; 0056; 0057; 0058, (2017/08/29)
The invention discloses a method for artificially synthesizing curcumin and a derivative thereof. The method comprises the steps of adopting calcium acetylacetonate as a acetylacetone supply source, carrying out claisen-schmidt ester condensation reaction on the calcium acetylacetonate and a corresponding benzaldehyde derivative, and dehydrating under the catalysis of a dehydrating agent which is tributyl borate to obtain a product intermediate (I) which is curcumin calcium salt; then hydrolyzing the intermediate (I) through a one-pot method to obtain a crude product, and purifying the crude product so as to obtain the final product curcumin and the derivative thereof. Compared with a acetylacetone boric acid complex method, according to the method provided by the invention, the calcium acetylacetonate is used, so that active sites of acetylacetonate during a reaction process are more accurate and activated, the generation of by-products is reduced, and the yield of the curcumin and the derivative thereof is improved.
A comparative study on the antioxidant properties of tetrahydrocurcuminoids and curcuminoids
Portes, Elise,Gardrat, Christian,Castellan, Alain
, p. 9092 - 9099 (2008/02/10)
Several curcuminoids and tetrahydrocurcuminoids (THCs), bearing various hydroxyl and/or methoxy groups on their benzene rings, have been synthesized to study their antioxidant and hydrogen donating capacities using the DPPH method at 25 °C in methanol. The results show that the tetrahydrocurcuminoids are in general much more efficient than their curcuminoid analogs if they include a phenol group in meta- or para-position of the linking chain and a neighboring phenol or methoxy group. This efficiency gain of THCs by comparison to curcuminoids was attributed to the presence of benzylic hydrogens involved in the oxidation process of these compounds and not to the beta-diketone moiety in the chain.
Synthesis of Naturally Occuring Curcuminoids and Related Compounds
Pedersen, Uffe,Rasmussen, Preben B.,Lawesson, Sven-Olov
, p. 1557 - 1569 (2007/10/02)
Six known naturally occuring curcuminoids like curcumin, and 31 other analogs (Scheme 1) have been synthesized.Among them, 25 curcuminoids were prepared by condensing different substituted 2,4-pentanediones and benzaldehydes.The boron complex 12 has been used to avoid Knoevenagel condensation at C-3 of 2,4-pentanedione.Some curcuminoids containing hydroxy groups in the aromatic moiety have been acylated.Alkylation of the tetrabutylammonium salt of 5-hydroxy-1,7-diphenyl-1,4,6-heptatrien-3-one (1a) by benzyl bromide gave only C-alkylated 4-benzyl-1,7-diphenyl-1,6-heptadiene-3,5-dione (1d*).The 13C NMR data, the UV absorptions, and the tautomerism of the curcuminoids are discussed.
