98889-55-5Relevant academic research and scientific papers
General Method for the Preparation of N3- and O4-Substituted Uridine Derivatives by Phase-Transfer Reactions
Sekine, Mitsuo
, p. 2321 - 2326 (2007/10/02)
A general method for regioselective introduction of a variety of protecting groups into the uracil residue of 1 has been developed by use of the phase-transfer reaction.Under such conditions, acyl groups such as benzoyl, p-toluyl, p-anisoyl, (2,2,2-trichl
Synthesis of C-5 and N-3 Arenesulfenyl Uridines. Preparation and Properties of a New Class of Uracil Protecting Group
Welch, C. J.,Bazin, H.,Heikkila, J.,Chattopadhyaya, J.
, p. 203 - 212 (2007/10/02)
The nature and position of the ring substituent of an arenesulfenyl chloride control the regiospecific formation of either a C-5 substituted product, as in compounds 3a-3d, or a N-3 substituted product, as in compound 2a-2c.Arenesulfenyl groups have been subsequently found to successfully protect the urethane function of the residue as exemplified by teh synthesis of 2'-O-methyl uridine and oligoribonucleotide building blocks.
