98923-51-4 Usage
Uses
Used in Pharmaceutical Industry:
3-(4-Chlorophenyl)-3-cyanopropionic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities and versatility in organic synthesis. It enables the creation of derivatives with different functional groups, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
3-(4-Chlorophenyl)-3-cyanopropionic acid is used as a starting material in the production of agrochemicals, such as pesticides and herbicides. Its unique chemical structure and potential biological activities make it a valuable component in the development of effective and environmentally friendly agrochemicals.
Used in Organic Synthesis:
3-(4-Chlorophenyl)-3-cyanopropionic acid is used as a versatile building block in organic synthesis for its ability to create various derivatives with different functional groups. This allows chemists to explore new chemical reactions and synthesize novel compounds with potential applications in various fields, including pharmaceuticals, materials science, and agrochemicals.
Used in Cyano-containing Compounds Synthesis:
3-(4-Chlorophenyl)-3-cyanopropionic acid is used as an important intermediate in the synthesis of cyano-containing compounds. Its presence of a cyano group makes it a valuable precursor for the development of new cyano-based compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 98923-51-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,9,2 and 3 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 98923-51:
(7*9)+(6*8)+(5*9)+(4*2)+(3*3)+(2*5)+(1*1)=184
184 % 10 = 4
So 98923-51-4 is a valid CAS Registry Number.
98923-51-4Relevant academic research and scientific papers
AN IMPROVED PROCESS FOR THE PREPARATION OF BACLOFEN AND ITS INTERMEDIATE
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Page/Page column 17, (2017/02/09)
The present invention provides an improved process for the preparation of 3-(4-chlorophenyl)-3- cyanopropanoic acid (compound (A)) and further its transformation to Baclofen (I). The process comprises reaction of compound (II) with Glyoxylic acid to obtain 3-(4-chlorophenyl)-3- cyanoacrylic acid (III); followed by the 'in- situ' reduction of (III) in the presence of a reducing agent to provide the compound (A). Alternatively, the compound (A) is obtained by the process comprising reacting 2-(4- chlorophenyl)acetonitrile (II) with haloacetic acid (IV) in the presence of a base. The compound 3-(4-chlorophenyl)-3-cyanopropanoic acid (A) undergoes hydrogenation in the presence of a metal catalyst and ammonia solution to provide Baclofen (I).
A short, chemoenzymatic route to chiral β-aryl-γ-amino acids using reductases from anaerobic bacteria
Fryszkowska, Anna,Fisher, Karl,Gardiner, John M.,Stephens, Gill M.
supporting information; experimental part, p. 533 - 535 (2010/05/11)
A short chemoenzymatic synthesis of β-aryl-γ-aminobutyric acids has been developed, based on a highly enantioselective biocatalytic reduction of β-aryl-β-cyano-α,β-unsaturated carboxylic acids.
