Concanamycin A is a naturally occurring polyketide macrolide compound that functions as a potent and selective inhibitor of vacuolar-type ATPase (V-ATPase). This enzyme is crucial for maintaining the pH and ion balance within cellular organelles like lysosomes and endosomes. By inhibiting V-ATPase, concanamycin A disrupts the acidification of these intracellular compartments, resulting in biological effects such as the inhibition of protein degradation, suppression of cell growth, and induction of apoptosis.
98932-70-8
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Basic information
- Product Name: CONCANAMYCIN A
- Synonyms: CONCANAMYCIN A;CONCANAMYCIN A, STREPTOMYCES SP;FOLIMYCIN;FOLIMYCIN, STREPTOMYCES SP;FOLIMYCIN, STREPTOMYCES SPECIES;Kitasamycin JPX IV
- CAS NO:98932-70-8
- Molecular Formula: C46H75NO14
- Molecular Weight: 866.09
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: CONCANAMYCIN A(CAS DataBase Reference)
- NIST Chemistry Reference: CONCANAMYCIN A(98932-70-8)
- EPA Substance Registry System: CONCANAMYCIN A(98932-70-8)
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Safety Data
- Hazard Codes: T+
- Statements: 26/27/28-36
- Safety Statements: 26-36/37/39-45
- RIDADR: UN 3462 6.1/PG 2
- WGK Germany: 3
- RTECS: CB9732000
- F: 10-21
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 98932-70-8(Hazardous Substances Data)
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98932-70-8 Usage
Uses
Used in Research Applications:Concanamycin A is utilized as a research tool to study the role of V-ATPase in cellular physiology and pathology. Its ability to block the acidification of intracellular compartments aids scientists in understanding the enzyme's function and its impact on various cellular processes.
Used in Pharmaceutical Development:
Due to its unique mechanism of action, concanamycin A holds potential therapeutic applications in the treatment of diseases such as cancer and osteoporosis. Its ability to inhibit cell growth and induce apoptosis makes it a promising candidate for developing drugs targeting these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 98932-70-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,9,3 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.Calculate Digit Verification of CAS Registry Number 98932-70:
(7*9)+(6*8)+(5*9)+(4*3)+(3*2)+(2*7)+(1*0)=188
188 % 10 = 8
So 98932-70-8 is a valid CAS Registry Number.
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CONCANAMYCIN A
