98952-77-3

Basic information

• Product Name: Benzonitrile, 4-[(2-hydroxyethyl)amino]-
• CAS NO: 98952-77-3
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Mol File: 98952-77-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[(2-hydroxyethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[(2-hydroxyethyl)amino]-(98952-77-3)
• EPA Substance Registry System: Benzonitrile, 4-[(2-hydroxyethyl)amino]-(98952-77-3)

Safety Data

• Hazardous Substances Data: 98952-77-3(Hazardous Substances Data)

Upstream product

• 75-21-8 oxirane 
• 873-74-5 4-Aminobenzonitrile 
• 78604-19-0 1-(p-cyanophenyl)-3-(2-chloroethyl)triazene 
• 107-07-3 2-chloro-ethanol 
• 1194-02-1 4-fluorobenzonitrile 
• 141-43-5 ethanolamine 

Downstream Products

• 635751-18-7 2-[[4-(aminocarbonyl)phenyl]amino]ethyl acetate 
• 635751-84-7 2-[[4-(aminocarbonyl)phenyl] [[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl acetate 
• 1610612-45-7 4-(2-(tert-butyldimethylsilyloxy)ethylamino)benzonitrile 
• 1448673-47-9 4-({2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]ethyl}amino)benzonitrile 
• 1448673-50-4 4-{[2-(aminooxy)ethyl]amino}benzenecarboximidamide 
• 1448673-48-0 4-{[2-(aminooxy)ethyl]amino}benzonitrile 
• 1021112-16-2 C₉H₁₂N₂O₂ 

Relevant articles and documents

ANTIBACTERIAL COMPOUNDS

The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

Syntheses of novel 1,3-diazaazulene derivatives and their nonlinear optical characterization

We have synthesized three new 1,3-diazaazulene derivatives, namely, 2-(4′-N,N-dimethylaminophenyl)-6-nitro-1,3-diazaazulene (18, DMAPNA), 2-(4′-aminophenyl)-6-nitro-1,3-diazaazulene (19, APNA) and 2-[4′-N-(2-hydroxyethyl)aminophenyl]-6-nitro-1,3-diazaazulene (20, HEAPNA), each of them contains an amino substitute as the electron donor (D), 2-phenyl-1,3-diazaazulene as the π-conjugated bridge and a nitro as the electron acceptor (A). Our theoretical results have predicted that these D-π-A type chromophores possess low ground-state dipole moment (μg) and large first-order hyperpolarizability (β), which may facilitate a low degree of aggregation for the chromophores dispersed in a polymeric matrix as well as a large nonlinear optical (NLO) response. The expected NLO performance has been confirmed by the experimental β and μg values, e.g., for 18, 407.8 × 10-30 esu and 4.7 D, respectively. The origins of large β and low μg are explained in terms of a two-state quantum model. The DMAPNA (18)-doped and poled polymethylmethacrylate film exhibits a large second harmonic generation (SHG) coefficient of d33 = 10.9 pm V-1 with excellent thermal stability (above 70% of the maximal SHG coefficient remains at ～100 °C). The Royal Society of Chemistry.