98960-08-8Relevant academic research and scientific papers
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design
Ann, Jihyae,Ha, Hee-Jin,Ha, Jung-Hye,Hoang, Van-Hai,Jang, Tae-ho,Kim, Hee,Kim, Young-Ho,Lee, Jeewoo,Lee, Jiyoun,Ngo, Van T. H.,Song, Jae Young,Van Manh, Nguyen
, (2021/09/20)
The inhibition of glutaminyl cyclase (QC) may provide a promising strategy for the treatment of early Alzheimer's disease (AD) by reducing the amount of the toxic pyroform of β-amyloid (AβΝ3pE) in the brains of AD patients. In this work, we ide
Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer
Chen, Jinying,Sang, Zitai,Jiang, Youjun,Yang, Chao,He, Linhong
, p. 232 - 241 (2018/11/02)
Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC50?=?31.1
