98965-25-4

Upstream product

• 95341-89-2 (S)-α-Methyl-N-(2-pyrrolylmethylen)phenylmethanamin 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 1003-29-8 2-pyrrole aldehyde 
• 1079-66-9 chloro-diphenylphosphine 
• 90472-43-8 (S)-1-phenyl-N-((pyrrol-2-yl)methyl)ethanamine 

Relevant academic research and scientific papers

Asymmetric Catalyses, 23. Optically Active Aminophosphanes - Synthesis and Use in the Rh-Catalyzed Enantioselective Hydrosilylation

New optically active P,N-ligands 6-15 were prepared by reaction of pyrrolimines, -amines, and pyridamines 1-5 with chlorophosphanes.With NEt3 as HCl scavenger the amine nitrogen NH groups were phosphinated selectively. n-BuLi as a base yielded a product mixture containing pyrrole nitrogen-phosphinated and doubly phosphinated compounds which could be separated by chromatography.On reaction with 2, the new P,N-ligands formed stable chelate complexes.In situ-catalysts from the optically active ligands 6-15 and 2 as well as the isolated Rh complexes 16-19 were used in the enantioselective hydrosilylation of acetophenone with diphenylsilane.Conversion and optical induction (up to 19.6percentee) in the formation of (+)- and (-)-phenylethanol depended on the Rh : ligand ratio, the Rh : substrate ratio, the reaction temperature, and the solvent.