98968-27-5

Upstream product

• 3922-47-2 3-amino-5-benzylthio<1,2,4>triazole 
• 3922-47-2 3-(benzylthio)-1H-1,2,4-triazol-5-amine 
• 98968-26-4 2-benzylthio-5,7-dihydroxy-1,2,4-triazolo<1,5-a>pyrimidine 

Downstream Products

• 98968-28-6 2-benzylthio-5-chloro-1,2,4-triazolo<1,5-a>pyrimidine 
• 98968-30-0 2-benzylthio-5-(2,2,2-trifluoroethoxy)-1,2,4-triazolo<1,5-a>pyrimidine 
• 98968-29-7 2-benzylthio-5-chloro-1,2,4-triazolo<1,5-a>pyrimidine 

Relevant academic research and scientific papers

Controlling substitution patterns on the 1,2,4-triazolo[1,5- a]pyrimidine ring. Selective removal of chlorine at the 7-position

A highly effective method for the selective removal of chlorine from the 7-position of the 1,2,4-triazolo[1,5-a]pyrimidine ring in the presence of chlorine at the 5- or 6-positions is reported. The method involves treatment of the appropriate substrate wi

Design and synthesis of N-2,6-difluorophenyl-5-methoxyl-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor

Triazolopyrimidine-2-sulfonamide belongs to a herbicide group called acetohydroxyacid synthase inhibitors. With the aim to discover new triazolopyrimidine sulfonanilide compounds with high herbicidal activity and faster degradation rate in soil, the methyl group of Flumetsulam (FS) was modified into a methoxy group to produce a new herbicidal compound, N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide (experimental code: Y6610). The enzymatic kinetic results indicated that compound Y6610 and FS have ki values of 3.31 × 10-6 M and 3.60 × 10-7 M against Arabidopsis thaliana AHAS, respectively. The 10-fold lower enzyme-inhibiting activity of Y6610 was explained rationally by further computational simulations and binding free energy calculations. In addition, compound Y6610 was found to display the same level in vivo post-emergent herbicidal activity as FS against some broad-leaf weeds and good safety to rice, maize, and wheat at the dosages of 75-300 g ai/ha. Further determination of the half-lives in soil revealed that the half-life in soil of Y6610 is 3.9 days shorter than that of FS. The experimental results herein showed that compound Y6610 could be regarded as a new potential acetohydroxyacid synthase-inhibiting herbicide candidate for further study.

Preparation of carbon-14 labeled N-(2,6-dichloro-3-methylphenyl)-5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidine-2 -sulfonamide

A new 6-step process was developed for the synthesis of radiolabeled metosulam, a broadleaf post emergent herbicide being commercialized by DowElanco for use in small grains. Each step of the process can be accomplished in >80% yield thereby making the pr

Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides

Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonamides, e.g., 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide and their agriculturally acceptable salts are prepared. These compounds and compositions containing them are useful for the control of unwanted vegetation. Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides and substituted anilines and their use as intermediates are also described.

Novel substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides and compositions and method for inhibiting pollen formation in corn

Novel compounds, e.g., 5,7-dimethyl-N-(2,6-dichlorolphenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide and their compositions and use in the control of weeds and in the suppression of nitrification of ammonium nitrogen in soil. Other novel compounds and their compositions and use in the inhibition of bolting in sugar beets. Other novel compounds and their compositions and use as plant gametocides.