98976-05-7Relevant academic research and scientific papers
Gram-Scale Synthesis of the (?)-Sparteine Surrogate and (?)-Sparteine
Firth, James D.,Canipa, Steven J.,Ferris, Leigh,O'Brien, Peter
, p. 223 - 226 (2018)
An 8-step, gram-scale synthesis of the (?)-sparteine surrogate (22 % yield, with just 3 chromatographic purifications) and a 10-step, gram-scale synthesis of (?)-sparteine (31 % yield) are reported. Both syntheses proceed with complete diastereocontrol and allow access to either antipode. Since the syntheses do not rely on natural product extraction, our work addresses long-term supply issues relating to these widely used chiral ligands.
