98977-39-0

Basic information

• Product Name: tert-butyl 1,3,5,6,7,8-hexahydro-3-oxo-4H-isoxazolo<4,3-c>azepine-5-carboxylate
• CAS NO: 98977-39-0
• Molecular Weight: 254.286
• Mol File: 98977-39-0.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 1,3,5,6,7,8-hexahydro-3-oxo-4H-isoxazolo<4,3-c>azepine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1,3,5,6,7,8-hexahydro-3-oxo-4H-isoxazolo<4,3-c>azepine-5-carboxylate(98977-39-0)
• EPA Substance Registry System: tert-butyl 1,3,5,6,7,8-hexahydro-3-oxo-4H-isoxazolo<4,3-c>azepine-5-carboxylate(98977-39-0)

Safety Data

• Hazardous Substances Data: 98977-39-0(Hazardous Substances Data)

Upstream product

• 61995-16-2 1-Benzyl-3,3-dihydroxypiperidine hydrobromide 
• 50717-82-3 piperidin-3-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 623-73-4 diazoacetic acid ethyl ester 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 98977-43-6 5,6,7,8-tetrahydro-4H-isoxazolo<4,3-c>azepin-3-ol zwitterion 

Relevant articles and documents

Glycine Antagonists. Synthesis, Structure, and Biological Effects of Some Bicyclic 5-Isoxazolol Zwitterions

The bicyclic 5-isoxazolol zwitterions 4,5,6,7-tetrahydroisoxazolopyridin-3-ol (3, iso-THPO), 5,6,7,8-tetrahydro-4H-isoxazoloazepin-3-ol (12, iso-THAO), and 5,6,7,8-tetrahydro-4H-isoxazoloazepin-3-ol (13, iso-THIA), which are structurally related to the glycine antagonist 5,6,7,8-tetrahydro-4H-isoxazoloazepin-3-ol (iso-THAZ), have been synthesized and tested biologically.All of these compounds were glycine antagonists approximetely equipotent with iso-THAZ during microelectrophoretic ejection near cat spinal neurons.In contrast to iso-THAZ, which also interacts with 4-aminobutyric acid (GABA) receptors in rat brains, neither 12 or 13 show any significant affinities for GABA binding or uptake mechanisms in vitro.The glycine antagonist 3 was, however, shown also to be a moderately potent inhibitor of GABA uptake.The structure of 12 was established by an X-ray analysis.The bond lengths of the 5-isoxazolol anionic moiety of 12 are in agreement with a pronounced delocalization of the negative charge of this compound.