98977-91-4Relevant academic research and scientific papers
Pt(0)-catalyzed alkynylation of aryl iodides with lithium alkynyltriisopropoxy borates
Oh, Chang Ho,Reddy, V. Raghava
, p. 2091 - 2094 (2004)
An efficient cross coupling reaction of various lithium alkynyltriiospropoxyborates with a wide array of aryl iodides was catalyzed by Pt(PPh3)4-CuI in DMF as a solvent. These cross coupling reactions are general and permit the new sp-sp2 carbon-carbon bond formation.
Synthesis and Structure-Activity Relationships of Naftifine-Related Allylamine Antimycotics
Stuetz, Anton,Georgopoulos, Apostolos,Granitzer, Waltraud,Petranyi, Gabor,Berney, Daniel
, p. 112 - 125 (2007/10/02)
Naftifine (1) is the first representative of the new antifungal allylamine derivatives.Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals.A tertiary allylamine function seems to be a prerequisite for activity against fungi.By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations.Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.
