98978-53-1

Upstream product

• 20697-12-5 (E)-N-((E)-3-phenylallylidene)naphthalen-1-amine 
• 134-32-7 1-amino-naphthalene 
• 87802-71-9 (E)-methyl cinnamyl carbonate 
• 14371-10-9 (E)-3-phenylpropenal 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 21040-45-9 Cinnamyl acetate 
• 673-32-5 1-Phenylprop-1-yne 

Downstream Products

• 98977-57-2 (E)-N-methyl-N-(3-phenyl-2-propenyl)-1-naphthalenamine 

Relevant academic research and scientific papers

Platinum-catalyzed allylation of aminonaphthalenes with allylic acetates in water

The activation of C-O bonds in allylic acetates in water as a suspension medium has been accelerated by carrying out the reactions in the presence of platinum complexes associated with ligands. The platinum-catalyzed allylation of aminonaphthalenes using allylic acetates gave the corresponding N-allylic aminonaphthalenes in good yields.

Magnetite (Fe3O4) silica based organic-inorganic hybrid copper(ii) nanocatalyst: A platform for aerobic N-alkylation of amines

A magnetically recoverable, efficient and selective copper based nanocatalyst has been synthesised via covalent grafting of 2-acetylthiophene on a silica coated magnetic nanosupport followed by metallation with copper acetate. The obtained organic-inorganic hybrid nanomaterial has been characterized by electron microscopy techniques (SEM and TEM with EDS), XRD, VSM, FT-IR and AAS. The catalytic performance of the novel nano-catalyst is evaluated in the active transformation of various aromatic amines to industrially-important alkylated amines. The nanocomposites afford high turnover frequency and high selectivity for amines under aerobic conditions. Furthermore, the heterogeneous nature of the catalyst allows easy magnetic recovery and regeneration, which makes the present protocol highly beneficial to address the industrial needs and environmental concerns.

Platinum-catalyzed allylation of aminonaphthalenes with allylic acetates

The activation of C-O bonds in allylic acetates has been accelerated by carrying out the reactions in the presence of platinum complexes associated with ligands. Platinum-catalyzed allylation of aminonaphthalenes with allylic acetates leads to N-allylic aminonaphthalenes in good yields.

Direct and indirect reductive amination of aldehydes and ketones with solid acid-activated sodium borohydride under solvent-free conditions

A simple and convenient procedure for reductive amination of aldehydes and ketones using sodium borohydride activated by boric acid, p-toluenesulfonic acid monohydrate or benzoic acid as reducing agent under solvent-free conditions is described.

Enantioselective allylation of aromatic amines after in situ generation of an activated cyclometalated iridium catalyst

Highly regio- and enantioselective allylation of aromatic amines is observed when a cyclometalated Ir-phosphoramidite complex is generated in situ (see scheme). The active catalyst can be formed from [{Ir(cod)Cl}2] and ligand L with a volatile alkylamine prior to addition of the reagents or upon use of a tertiary amine additive.

A convenient and efficient route for the allylation of aromatic amines and α-aryl aldehydes with alkynes in the presence of a Pd(0)TPhCOOH combined catalyst system

The allylation of aromatic amines with alkynes proceeded smoothly in the presence of catalytic amounts of Pd(PPh3)4 and benzoic acid. The allylation products were obtained in high yields in a regio- and stereoselective manner. The effect of various groups on the nitrogen atom of anilines was studied. Regardless of the substituent (electron withdrawing or electron donating) on the aromatic ring, the reaction proceeded well. Various functionalities, including -CH3, -OMe, -Cl, -CN, -COOMe, -NO 2 and -COCH3 were tolerated under the reaction conditions. Similarly, the allylation of α-aryl aldehydes proceeded well with the same level of regio- and stereoselectivity as the allylation of aromatic amines. This reaction provides the second example of the transition metal catalyzed direct α-allylation of aldehydes.

Direct palladium(0)-catalyzed amination of allylic alcohols with aminonaphthalenes

The direct activation of C-O bonds in allylic alcohols by palladium complexes has been accelerated by carrying out the reactions in the presence of titanium reagents. The palladium-catalyzed amination of allylic alcohols using aminonaphthalenes gave N-all

Synthesis and Structure-Activity Relationships of Naftifine-Related Allylamine Antimycotics

Naftifine (1) is the first representative of the new antifungal allylamine derivatives.Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals.A tertiary allylamine function seems to be a prerequisite for activity against fungi.By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations.Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.