98986-07-3Relevant academic research and scientific papers
Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-α suppression and IL-10 augmentation
Hanano, Tokushi,Adachi, Kunitomo,Aoki, Yoshiyuki,Morimoto, Hiroshi,Naka, Yoichi,Hisadome, Masao,Fukuda, Tetsuko,Sumichika, Hiroshi
, p. 881 - 884 (2000)
A series of arylpiperazine derivatives was synthesized to obtain agents showing apparent therapeutic effects in a chronic inflammatory animal model, starting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidylpipe
