98998-40-4

Usage

Explanation

The compound has a molecular formula of C8H16N2OS, which indicates the number of carbon, hydrogen, nitrogen, oxygen, and sulfur atoms in the molecule.

Explanation

The compound is also known by this alternative name, which provides a more detailed description of its chemical structure.

Explanation

The compound belongs to a class of organic thioamides that are derived from piperazine, a heterocyclic organic compound.

Explanation

1-Piperazinecarbothioic acid, 4-methyl-, O-ethylester is used in the production of various pharmaceuticals due to its chemical properties.

Explanation

The compound serves as a chemical intermediate in organic synthesis, which means it is used as a starting material or building block in the synthesis of other organic compounds.

Explanation

The compound has potential applications in the treatment of parasitic infections, although further research and development may be required for its use in this context.

Explanation

It is important to handle 1-Piperazinecarbothioic acid, 4-methyl-, O-ethylester with care, as it is a toxic and harmful compound that can pose risks to human health and the environment.

Classification

Organic thioamide derivative of piperazine

Use in pharmaceuticals

Manufacture of pharmaceuticals

Chemical intermediate

Organic synthesis

Potential application

Treatment of parasitic infections

Toxicity

Toxic and harmful nature

Upstream product

• 109-01-3 1-methyl-piperazine 
• 89532-51-4 1H-imidazole-1-carbothioic acid O-ethyl ester 
• 142274-14-4 Carbonodithiosaeure-O-ethyl-S-(2-hydroxy-4-oxo-4-phenylbutyl)ester 

Relevant academic research and scientific papers

Discovery of small molecules with vasodilating characteristics and adjustable hydrolytic behavior

In this contribution the development of a new class of vasodilating compounds obtained by lead structure optimization is described. Three groups of compounds were synthesized and tested for their activity on various smooth muscle preparations of the Guinea pig. Beside the lead compound 3a, the most interesting derivative was 1H-imidazole-1-carbothioic acid O-cyclohexyl ester hydrochloride (5b) with a good selective vasodilating potential on aorta and pulmonary artery rings (EC50 14 μM and 24 μM, respectively). Due to the properties of small molecules the hydrolysis behavior of the compounds can be easily adapted hence opening a new route in terms of duration of the agent's effect. With the aid of structure-activity relationship studies, structural motifs influencing the biological activity on isolated smooth muscle cell preparations of the synthesized compounds were proposed. The presented compounds offer good tools in identifying promising molecules as emergency therapy in myocardial infarction.

72. Synthesis of 2-Substituted and 2,3-Disubstituted Alkyl-and Aryl-thiophenes and Related 2,3-Anellated Thiophene Derivatives, Using Ketones and Carbonodithioic Acid O-Ethyl S-(2-Oxoethyl) Ester as the Building Blocks

A simple method to synthesize 2-substituted and 2,3-disubstituted alkyl- and aryl-thiophenes as well as related 2,3-anellated thiophenes 6, starting from ketones 1 as C2-fragment and the S-protected carbonodithionic-acid derivative 3 as a C2S-fragment is described.The aldols 4 are intermediates of the two step process.