99-23-0Relevant articles and documents
A concise total synthesis of puberulic acid, a potent antimalarial agent
Sennari, Goh,Hirose, Tomoyasu,Iwatsuki, Masato,Omura, Satoshi,Sunazuka, Toshiaki
, p. 8715 - 8718 (2014/07/22)
Efficient and practical total synthesis of puberulic acid has been accomplished via 8 steps, with 54% overall yield, and only two C-C bond formations, without the introduction of oxygen atoms into the core skeleton. Construction of the tropolone framework as the key transformation was achieved by multi-tandem oxidation of the aliphatic-triol, from d-(+)-galactose as the starting material.
