99011-78-6

Basic information

• Product Name: IMiquiMod (hydrochloride)
• Synonyms: IMiquiMod (hydrochloride)
• CAS NO: 99011-78-6
• Molecular Formula: C14H17ClN4
• Molecular Weight: 276.76458
• Mol File: 99011-78-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300 °C
• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: ≥3.59 mg/mL in EtOH with ultrasonic; ≥5.54 mg/mL in DMSO with gentle warming and ultrasonic; ≥7.34 mg/mL in H2O with ultrasonic
• CAS DataBase Reference: IMiquiMod (hydrochloride)(CAS DataBase Reference)
• NIST Chemistry Reference: IMiquiMod (hydrochloride)(99011-78-6)
• EPA Substance Registry System: IMiquiMod (hydrochloride)(99011-78-6)

Safety Data

• Hazardous Substances Data: 99011-78-6(Hazardous Substances Data)

Usage

Biological Activity

imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.

Upstream product

• 960254-02-8 5-(2-aminophenyl)-1-(2-methylpropyl)-1H-imidazole-4-carbonitrile 
• 960254-00-6 5-iodo-1-isobutyl-1H-imidazole-4-carbonitrile 
• 960253-98-9 5-amino-1-isobutyl-1H-imidazole-4-carbonitrile 

Relevant articles and documents

Ring Closing and Related Methods and Intermediates

Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:

PREPARATION OF 1H-IMIDAZO [4,5-C] QUINOLIN-4-AMINES VIA NOVEL 1H-IMIDAZO [4,5-C] QUINOLIN-4-CYANO AND 1H-IMIDAZO [4,5-C] QUINOLIN-4-CARBOXAMIDE INTERMEDIATES

The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4- carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo [4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4- carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo [4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.