99012-87-0Relevant academic research and scientific papers
Polycyclic Aryl- and Heteroarylpiperazinyl Imides as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents: Synthesis and Structure-Activity Relationship
Abou-Gharbia, Magid,Patel, Usha R.,Webb, Michael B.,Moyer, John A.,Andree, Terrance H.,Muth, Eric A.
, p. 1382 - 1392 (2007/10/02)
A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests.Parameters measured included in vitro inhibition of D2 and 5-HT1A receptor binding, inhibition of
N-(substituted piperazinyl) alkylbicyclic succinimide derivatives
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, (2008/06/13)
A succinimide derivative of the formula: STR1 wherein A is straight or branched C2 -C6 alkylene or alkenylene, B is straight or branched C3 -C5 alkylene, D is straight or branched C2 -C3 alkylene, E is straight or branched C2 -C3 alkylene, R1 and R2 are each hydrogen or C1 -C4 alkyl, or they may form a single bond and R3 is a phenyl group optionally substituted with C1 -C4 alkyl, C1 -C4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: STR2 (in which R4 is hydrogen or phenyl), a group of the formula: CO--R5 (in which R5 is adamantyl or furyl) or hydroxy (C2 -C4) alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.
