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99025-94-2

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99025-94-2 Usage

General Description

N-Benzyl-3-(hydroxymethyl)azetidine is a chemical compound with the molecular formula C13H17NO. It is a heterocyclic organic compound that contains a five-membered azetidine ring and a benzyl group. The compound has a hydroxymethyl functional group located at the third carbon of the azetidine ring. It can be used in organic synthesis and pharmaceutical research, and it may exhibit potential biological activity due to its unique structure. Further research and analysis are needed to fully understand the properties and potential applications of N-Benzyl-3-(hydroxymethyl)azetidine.

Check Digit Verification of cas no

The CAS Registry Mumber 99025-94-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,2 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 99025-94:
(7*9)+(6*9)+(5*0)+(4*2)+(3*5)+(2*9)+(1*4)=162
162 % 10 = 2
So 99025-94-2 is a valid CAS Registry Number.

99025-94-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (1-benzylazetidin-3-yl)methanol

1.2 Other means of identification

Product number -
Other names HT771

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:99025-94-2 SDS

99025-94-2Relevant articles and documents

Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil

van Greunen, Divan G.,Cordier, Werner,Nell, Margo,van der Westhuyzen, Chris,Steenkamp, Vanessa,Panayides, Jenny-Lee,Riley, Darren L.

, p. 671 - 690 (2017/02/10)

A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which is currently used for the management of mild to severe Alzheimer's disease. Two series of analogues were prepared, the first looking at the replacement of the piperidine ring in donepezil with different sized saturated N-containing ring systems and the second looking at the introduction of different linkers between the indanone and piperidine rings in donepezil. The most active analogue 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl 1-benzylpiperidine-4-carboxylate (67) afforded an in vitro IC50value of 0.03 ± 0.07 μM against acetylcholinesterase with no cytotoxicity observed (IC50of >100 μM, SH-SY5Y cell line). In comparison donepezil had an IC50of 0.05 ± 0.06 μM and an observed cytotoxicity IC50of 15.54 ± 1.12 μM. Molecular modelling showed a strong correlation between activity and in silico binding in the active site of acetylcholinesterase.

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

Evans, Gary B.,Furneaux, Richard H.,Greatrex, Ben,Murkin, Andrew S.,Schramm, Vern L.,Tyler, Peter C.

, p. 948 - 956 (2008/09/19)

N-Ribosyl phosphorylases and hydrolases catalyze nucleophilic displacement reactions by migration of the cationic ribooxacarbenium carbon from the fixed purine to phosphate and water nucleophiles, respectively. As the lysis reaction progresses along the r

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