99032-02-7

Upstream product

• 74400-30-9 (1R,7aS)-1-Hydroxy-7-hydroxymethyl-1,2,5,7a-tetrahydro-pyrrolizin-3-one 
• 74400-35-4 (Z)-3-(Tetrahydro-pyran-2-yloxymethyl)-penta-2,4-dien-1-ol 
• 74400-34-3 (Z)-3-(Tetrahydro-pyran-2-yloxymethyl)-penta-2,4-dienoic acid methyl ester 
• 74400-41-2 Methanesulfonic acid (E)-3-[3-(tert-butyl-dimethyl-silanyloxy)-5-oxo-pyrrolidin-2-yl]-4-(tetrahydro-pyran-2-yloxy)-but-2-enyl ester 
• 74400-32-1 (1R,7aS)-1-(tert-Butyl-dimethyl-silanyloxy)-7-(tetrahydro-pyran-2-yloxymethyl)-1,2,5,7a-tetrahydro-pyrrolizin-3-one 
• 74400-38-7 C₃₅H₄₇NO₅Si 
• 74400-37-6 C₂₉H₃₃NO₅ 
• 70866-61-4 5-(tert-Butyl-dimethyl-silanyloxy)-4-(tetrahydro-pyran-2-yloxymethyl)-2,4a,5,6-tetrahydro-pyrrolo[1,2-b][1,2]oxazin-7-one 
• 70866-60-3 4-(tert-Butyl-dimethyl-silanyloxy)-5-[(E)-3-hydroxy-1-(tetrahydro-pyran-2-yloxymethyl)-propenyl]-pyrrolidin-2-one 
• 74400-36-5 (Z)-3-(Tetrahydro-pyran-2-yloxymethyl)-penta-2,4-dienal 

Downstream Products

• 115509-99-4 (-)-intermedine 
• 109363-22-6 (-)-indicine 

Relevant academic research and scientific papers

Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: Enantiocontrol and applications in synthesis

(Chemical Equation Presented) All adducts one way: Iminium ions, generated in situ from the corresponding N,O-acetals, can be used as electrophiles in a Morita-Baylis-Hillman-type reaction with a wide range of Michael acceptors (enones, enals, S- and O-acrylates). The reaction has been rendered asymmetric using sulfide 1 (see scheme; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene, TMSOTf=trimethylsilyl trifluoromethanesulfonate).