99055-55-7 Usage
Uses
Used in Medicinal Chemistry:
N-(1H-Indazol-6-yl)thiourea is used as a compound with potential biological activity for various medicinal applications. Its presence in the indazole class suggests that it may have properties that could be harnessed in the development of new pharmaceuticals or in research studies aimed at understanding the mechanisms of action of related compounds.
Used in Research and Development:
N-(1H-Indazol-6-yl)thiourea is used as a research chemical to explore its properties and potential interactions with biological systems. This can include studies on its chemical reactivity, stability, and how it might be modified or synthesized for specific applications in the field of chemistry and medicine.
It's important to note that while handling this chemical, standard procedures for dealing with chemicals should be followed to ensure safety, as is the case with any chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 99055-55-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,5 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 99055-55:
(7*9)+(6*9)+(5*0)+(4*5)+(3*5)+(2*5)+(1*5)=167
167 % 10 = 7
So 99055-55-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N4S/c9-8(13)11-6-2-1-5-4-10-12-7(5)3-6/h1-4H,(H,10,12)(H3,9,11,13)
99055-55-7Relevant academic research and scientific papers
Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors
Kang, Iou-Jiun,Wang, Li-Wen,Yeh, Teng-Kuang,Lee, Chung-Chi,Lee, Yen-Chun,Hsu, Sheng-Ju,Wu, Yen-Shian,Wang, Jing-Chyi,Chao, Yu-Sheng,Yueh, Andrew,Chern, Jyh-Haur
experimental part, p. 6414 - 6421 (2010/10/04)
A series of novel conformationally-restricted thiourea analogs were designed, synthesized, and evaluated for their anti-HCV activity. Herein we report the synthesis, structure-activity relationships (SARs), and pharmacokinetic properties of this new class of thiourea compounds that showed potent inhibitory activities against HCV in the cell-based subgenomic HCV replicon assay. Among compounds tested, the fluorene compound 4b was found to possess the most potent activity (EC50 = 0.3 μM), lower cytotoxicity (CC50 > 50 μM), and significantly better pharmacokinetic properties compared to its corresponding fluorenone compound 4c.
