99056-35-6 Usage
Description
ETHYL 2-METHYL-7-OXO-4,7-DIHYDROPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE is a chemical compound that belongs to the pyrazolo[1,5-a]pyrimidine class. It is an ester of 2-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid. ETHYL 2-METHYL-7-OXO-4,7-DIHYDROPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE has potential pharmaceutical applications due to its various biological activities, such as anti-inflammatory and antitumor properties. Its chemical structure features a pyrazolo[1,5-a]pyrimidine core, making it a valuable intermediate for the synthesis of new drug candidates. The presence of an ethyl ester group allows for easy manipulation and modification of its chemical properties, making it a versatile compound in drug discovery and development.
Uses
Used in Pharmaceutical Industry:
ETHYL 2-METHYL-7-OXO-4,7-DIHYDROPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE is used as a pharmaceutical intermediate for the development of new drug candidates due to its versatile chemical properties and potential biological activities, such as anti-inflammatory and antitumor effects.
Used in Drug Synthesis:
ETHYL 2-METHYL-7-OXO-4,7-DIHYDROPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE is used as a key intermediate in the synthesis of various pharmaceutical compounds, leveraging its pyrazolo[1,5-a]pyrimidine core and ethyl ester group for easy manipulation and modification of chemical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 99056-35-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,5 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 99056-35:
(7*9)+(6*9)+(5*0)+(4*5)+(3*6)+(2*3)+(1*5)=166
166 % 10 = 6
So 99056-35-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H11N3O3/c1-3-16-10(15)7-5-11-8-4-6(2)12-13(8)9(7)14/h4-5,11H,3H2,1-2H3
99056-35-6Relevant articles and documents
Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB2 cannabinoid receptor inverse agonists
Aghazadeh Tabrizi, Mojgan,Baraldi, Pier Giovanni,Saponaro, Giulia,Moorman, Allan R.,Romagnoli, Romeo,Preti, Delia,Baraldi, Stefania,Ruggiero, Emanuela,Tintori, Cristina,Tuccinardi, Tiziano,Vincenzi, Fabrizio,Borea, Pier Andrea,Varani, Katia
, p. 4482 - 4496 (2013/07/19)
We recently described the medicinal chemistry of a new series of heteroaryl-4-oxopyridine/7-oxopyrimidines as CB2 receptor partial agonists, showing that the functionality of these ligands is controlled by the nature of the heteroaryl function condensed with the pyridine ring. We describe herein the design and synthesis of the 7-oxopyrazolo[1,5-a]pyrimidine-6- carboxamides, structural isomers of our previously reported pyrazolo[3,4-b] pyridines. All of the new compounds showed high affinity and selectivity for the CB2 receptor in the nanomolar range. In 3,5-cyclic adenosine monophosphate (cAMP) assays, the novel series shows stimulatory effects on forskolin-induced cAMP production acting as inverse agonists.