99056-41-4Relevant academic research and scientific papers
Design and synthesis of a new class of N-arylsulfonylaminated pyridones
Elgemeie, Galal H.,Elghandour, Ahmed H.,Elzanate, Ali M.,Masoud, Wafaa A.
, p. 91 - 97 (2000)
A novel synthesis of N-arylsulfonylamino-2-pyridones via reaction of arylmethylenemalononitriles with cyanoacetyl-N-arylsulfonylhydrazides is reported and the synthetic potential of the method is demonstrated.
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays
Myers, Michael C.,Napper, Andrew D.,Motlekar, Nuzhat,Shah, Parag P.,Chiu, Chun-Hao,Beavers, Mary Pat,Diamond, Scott L.,Huryn, Donna M.,Smith III, Amos B.
, p. 4761 - 4766 (2008/02/11)
Substituted pyrazole esters were identified as hits in a high throughput screen (HTS) of the NIH Molecular Libraries Small Molecule Repository (MLSMR) to identify inhibitors of the enzyme cathepsin B. Members of this class, along with functional group analogs, were synthesized in an effort to define the structural requirements for activity. Analog characterization was hampered by the need to include a reducing agent such as dithiothreitol (DTT) or cysteine in the assay, highlighting the caution required in interpreting biological data gathered in the presence of such nucleophiles. Despite the confounding effects of DTT and cysteine, our studies demonstrate that the pyrazole 1 acts as alternate substrate for cathepsin B, rather than as an inhibitor.
Regioselective synthesis of a new class of N-arylsulfonylaminated biheterocycles
Elgemeie, Galal Hamza,Sayed, Shahinaz Hassan
, p. 465 - 473 (2007/10/03)
A novel and efficient method for the synthesis of a new variety of novel N-arylsulfonylamino derivatives of biheterocycles by the reaction of N-cyanoaceto-arylsulphonylhydrazides with α,β-unsaturated nitriles. The synthetic potential of the method is demonstrated.
Regioselective synthesis of a new class of N-arylsulfonylaminated biheterocycles
Elgemeie, Galal Hamza,Sayed, Shahinaz Hassan
, p. 587 - 592 (2007/10/03)
A novel and efficient method for the synthesis of a new variety of novel N-arylsulfonylamino derivatives of biheterocycles by the reaction of N-cyanoaceto-arylsulphonylhydrazides with α,β-unsaturated nitriles. The synthetic potential of the method is demonstrated.
A new general method for substituted 4-alkylthio-N-arylsulphonyl-amino-2-pyridones: Reaction of ketene-ss-acetals with arylsulphonylhydrazides
Elgemeie, Galal H.,Ali, Hosny A.,Elghandour, Ahmed H.,Abdel-Aziz, Hassan M.
, p. 171 - 179 (2007/10/03)
A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.
A Novel And Efficient Method For Synthesis Of N-Arylsulphonylamino-2-Pyridones
Elgemeie, Galal H.,Elghandour, Ahmed H. H.,Ali, Hosny A.,Abdel-Azzez, Hassan M.
, p. 141 - 150 (2007/10/03)
A novel and efficient method for the synthesis of N-arylsulphonylamino-2-pyridones via the reaction of N-cyanoacetohydrazides with ethyl arylidenecyanoacetate derivatives has been investigated. N-sulphonated aminopyridines are also prepared from the reaction of N-amino-2-pyridone with arylsulphonyl chlorides.
Novel synthesis of 5-amino-1-arylsulfonyl-4-pyrazolin-3-ones as a new class of N-sulfonylated pyrazoles
Elgemeie, Galal H.,Metwally, Nadia H.
, p. 384 - 385 (2007/10/03)
A novel synthesis of 5-amino-1-arylsulfonyl-4-pyrazolin-3-ones via intramolecular cyclization of cyanoaceto-N-arylsulfonylhydrazides is reported and the synthetic potential of the method is demonstrated.
