99059-30-0Relevant academic research and scientific papers
Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition
Bhatt, Aaditya,Gurukumar,Basu, Amartya,Patel, Maulik R.,Kaushik-Basu, Neerja,Talele, Tanaji T.
, p. 5138 - 5145 (2011)
Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Here we report the synthesis and biological evaluation of a new series of α,γ-diketo acids (DKAs) as NS5B polymerase inhibitors. We initiated structure-activity
