99059-64-0 Usage
Uses
Used in Pharmaceutical Industry:
3-Iodo-4-(propan-2-yl)benzoic acid is used as a reactant for the preparation of novel ponatinib analogs, which are potent fibroblast growth factor receptor (FGFR) inhibitors. These analogs have potential applications in the treatment of various cancers and other diseases by targeting the FGFR signaling pathway, which plays a crucial role in cell proliferation, survival, and differentiation.
Used in COVID-19 Research:
3-Iodo-4-(propan-2-yl)benzoic acid is also a COVID-19-related research product, indicating its potential involvement in the development of therapeutic agents or vaccines against the SARS-CoV-2 virus. Its unique chemical properties may contribute to the discovery of new antiviral compounds or the enhancement of existing ones to combat the ongoing pandemic.
Check Digit Verification of cas no
The CAS Registry Mumber 99059-64-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,5 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 99059-64:
(7*9)+(6*9)+(5*0)+(4*5)+(3*9)+(2*6)+(1*4)=180
180 % 10 = 0
So 99059-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H11IO2/c1-6(2)8-4-3-7(10(12)13)5-9(8)11/h3-6H,1-2H3,(H,12,13)
99059-64-0Relevant academic research and scientific papers
Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders
Xie, Zhicheng,Wu, Bing,Liu, Yingqiang,Ren, Wenming,Tong, Linjiang,Xiang, Caigui,Wei, Aihuan,Gao, Yuanzhuo,Zeng, Limin,Xie, Hua,Tang, Wei,Hu, Youhong
, p. 1397 - 1414 (2020/02/04)
Colony-stimulating factor 1 receptor (CSF-1R) is involved in inflammatory disorders as well as in many types of cancer. Based on high-throughput screening and docking results, we performed a detailed structure-activity-relationship study, leading to the d
