99067-42-2

Upstream product

• 2475-92-5 4-methoxyacetophenone oxime 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1115951-73-9 1-(3-bromo-4-methoxy-phenyl)-2-piperidin-1-yl-ethane-1,2-dione 
• 1115951-74-0 1-(3-bromo-4-methoxy-phenyl)-2-pyrrolidin-1-yl-ethane-1,2-dione 

Relevant academic research and scientific papers

Synthesis of dibromo ketones by the reaction of the environmentally benign H2O2-HBr system with oximes

It was found that oximes undergo deoximation in the presence of the H2O2aq-HBraq system to form ketones and bromo ketones. This reaction provided the basis for the synthesis of dibromo ketones in yields varying from 40% to 94%. This method is environmentally friendly, sustainable, and easy to perform. The results of this investigation extend the potential of the use of oximes for the protection of carbonyl group, thus offering the ability to perform not only conventional deoximation but also the subsequent bromination of ketones. The reaction is easily scaled up and dibromo ketones can be prepared in gram amounts. Versita Sp. z o.o.

A convenient synthesis of 2,2-dibromo-1-arylethanones by bromination of 1-arylethanones with the H2O2-HBr system

1-Arylethanones and related compounds are brominated in dioxane with the H2O2-HBraq system, resulting in the replacement of two hydrogen atoms in the methyl group with bromine. The reaction is also accompanied by bromination of the aromatic ring provided that the latter contains electron-donating substituents. The reaction proceeds rapidly (20 min) and results in complete conversion of ketones to give 2,2-dibromo-1- arylethanones in yields up to 86%. Georg Thieme Verlag Stuttgart.

Halogenated 4'-methoxyacetophenones as microbicides and preservatives

Halogenated 4'-methoxyacetophenones of formula I: STR1 wherein X is a halogen; Y is a halogen; and n is 1 or 2 as microbicides for inhibiting the growth of microorganisms in aqueous systems and on surfaces, as well as for inhibiting slime formation in aqueous systems and biocidal compositions containing effective amounts of the halogenated 4'-methoxyacetophenones.