99067-92-2Relevant articles and documents
Domino reaction of a gold catalyzed 5-: Endo-dig cyclization and a [3,3]-sigmatropic rearrangement towards polysubstituted pyrazoles
Verlee, Arno,Heugebaert, Thomas,Van Der Meer, Tom,Kerchev, Pavel,Van Breusegem, Frank,Stevens, Christian V.
, p. 9359 - 9363 (2018)
Pyrazoles are important heterocyclic compounds with a broad range of biological activities. A new procedure toward tri- or tetrasubstituted pyrazoles has been developed, via a one-pot gold catalyzed synthesis from hydrazines with alkynyl aldehydes or keto
The Use of Potassium/Sodium Nitrite as a Nitrosating Agent in the Electrooxidative N-Nitrosation of Secondary Amines
Chen, Zuxing,Gao, Meng,Lu, Cuifen,Ma, Chao,Ruan, Mengyao,Wang, Feiyi,Wang, Ying,Yang, Guichun,You, Shiqi
supporting information, p. 3289 - 3293 (2021/07/02)
We report herein on the electrochemical N-nitrosation of secondary amines using widely available sodium/potassium nitrite as a nitrosating agent. This approach not only eliminates the need for using a combination of sodium/potassium and a strong acid but also has good functional group tolerance. The reaction is compatible with the late-stage modification of pharmaceutical compounds and could be conducted in gram scale with a high reaction efficiency. Preliminary mechanistic studies indicate that the N-nitrosation occurs via the anodic oxidation of KNO2 into an NO2 radical which is then transformed into an NO+ cation.
