99071-38-2Relevant academic research and scientific papers
PIDA-mediated oxidative aromatic C[sbnd]N bond cleavage: Efficient methodology for the synthesis of 1,2-diaza-1,3-dienes under ambient conditions
Kumar, Abhishek,Katiyar, Sarita,Kumar Jaiswal, Arvind,Kant, Ruchir,Sashidhara, Koneni V.
, (2021)
A series of functionalized 1,2-diaza-1,3-diene derivatives were synthesized from 5–aminopyrazoles via oxidative cleavage of the aromatic C[sbnd]N bond under transition metal-free conditions. A control experiment revealed that the presence of a free NHsub
Cu(I)/Fe(III) promoted dicarbonylation of aminopyrazole via oxidative C–H coupling with methyl ketones
Rastogi, Gaurav K.,Saikia, B-Shriya,Pahari, Pallab,Deb, Mohit L.,Baruah, Pranjal K.
supporting information, p. 1189 - 1192 (2019/03/27)
Cu(I)/Fe(III) promoted C4-dicarbonylation of 5-aminopyrazole is developed. The strategy involved radical triggered direct oxidative coupling of 5-aminopyrazoles with methyl ketones using aerial oxygen as a source of oxygen in newly generated carbonyl group. CuI is used as catalyst and FeCl3·6H2O is used as additive and the reaction proceeded at 120 °C in DMSO for 9–12 h. It is found that use of Cu(II) catalyst gives the thiomethylated product by reacting with DMSO instead of oxidative coupling. A plausible mechanism is also given.
