99108-14-2Relevant academic research and scientific papers
3-carbamoyl- and 3-thiocarbamoyl-tetrahydro-1,3-thiazine-2-thiones and skin treating compositions containing the same
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, (2008/06/13)
New 3-carbamoyl- and 3-thiocarbamoyl-tetrahydro-1,3-thiazine-2-thiones are disclosed as skin treatment compositions based upon physiologically-compatible carriers and a content of these compounds as active substance for increasing the skin protection, in particular against sun radiation and contact with environmental substances of all types. The skin treatment compositions are also suitable for prophylactic control of so-called aging skin. The compositions are applied to the skin one or two times daily for about 3-4 weeks.
Investigations on 1,3 Thiazines, 35. - Oxidations of Thiocarbamidates, 9. - Unusual Rearrangement Upon Thiocarbamoylation of Tetrahydro-2H-1,3-thiazin-2-one
Hanefeld, Wolfgang,Guenes, Zeynel E.
, p. 1140 - 1146 (2007/10/02)
During thiocarbamoylation of tetrahydro-2H-1,3-thiazin-2-one (4) with N,N-disubstituted thiocarbamoyl chlorides the 3-carboxamides 2 were isolated besides the expected 3-thiocarboxamides 6.The carboxamides 2 are interpreted as products of initial O-thiocarbamoylation, subsequent Newman-Kwart rearrangement, and final S->N-transcarbamoylation.Structures were ensured by independent syntheses and 13C-NMR spectroscopy.Thiocarbamidate and thiourea substructures were converted into the corresponding oxygen analogues by oxidative desulfurisation.
1,3-Thiazines, XXVI: Novel N-Carbamoyl- and Thiocarbamoyl-2-thioxo-1,3-thiazine Derivatives
Hanefeld, Wolfgang,Bercin, Erdogan
, p. 848 - 854 (2007/10/02)
The N-unsubstituted 1,3-thiazine derivatives 1-3 were transformed into the N-carbamoyl- or N-thiocarbamoyl-1,3-thiazine derivatives 5-9 by carbamic acid chlorides or thiocarbamic acid chlorides in the presence of triethylamine or sodium hydride.
