99129-15-4Relevant academic research and scientific papers
MACROCYCLISATION EN SERIES LACTONE, THIOLACTONE et LACTAME a MOTIF ETHYLENE DIOXY. EFFETS de MATRICE du SILICIUM et de l'ETAIN
Leygue, N.,Picard, C.,Tisnes, P.,Cazaux, L.
, p. 5845 - 5856 (2007/10/02)
The orientation of the macrocyclization reaction leading to the di or tetrafunctional titled compounds has been studied for 12 and 24 membered rings containing ethylene dioxy moieties.The reactions were carried out from not activated diol, dithiol or diamine and from their silyl and stannyl derivatives.They were not performed at high dilution.The intracyclic oxygen atoms had a strong influence on the orientation of the cyclisation towards the monomer.However, it was also possible to obtain the dimeric forms with yields ranging from 10 to 40percent.
Macrocyclic Polylactams of Mirror Symmetry: Preparation and Structure
Schwartz, Eduard,Gottlieb, Hugo E.,Frolow, Felix,Shanzer, Abraham
, p. 5469 - 5476 (2007/10/02)
The synthesis and structure of a series of macrocyclic lactams possessing reflection symmetry are described.The synthesis involves condensation of diazasilolidines 1 and 2 with diacyl dihalides 3 to give either exclusively macrocyclic dilactams 4 or tetralactams 5.The high product selectivity of these reactions is attributed to noncovalent interactions between silicon and carbonyl oxygen.The structures of the macrocyclic lactams prepared are analyzed by high-resolution 1H and 13C NMR spectrometry as well by X-ray diffraction studies.The observed conformational regularities are discussed and compared with those of macrocyclic lactams of rotational symmetry.
