99129-20-1Relevant academic research and scientific papers
Macrocyclic Polylactams of Mirror Symmetry: Preparation and Structure
Schwartz, Eduard,Gottlieb, Hugo E.,Frolow, Felix,Shanzer, Abraham
, p. 5469 - 5476 (2007/10/02)
The synthesis and structure of a series of macrocyclic lactams possessing reflection symmetry are described.The synthesis involves condensation of diazasilolidines 1 and 2 with diacyl dihalides 3 to give either exclusively macrocyclic dilactams 4 or tetralactams 5.The high product selectivity of these reactions is attributed to noncovalent interactions between silicon and carbonyl oxygen.The structures of the macrocyclic lactams prepared are analyzed by high-resolution 1H and 13C NMR spectrometry as well by X-ray diffraction studies.The observed conformational regularities are discussed and compared with those of macrocyclic lactams of rotational symmetry.
