99131-38-1

Basic information

• Product Name: GRDGS
• Synonyms: GRDGS;GLY-ARG-ASP-GLY-SER;H-GLY-ARG-ASP-GLY-SER-OH
• CAS NO: 99131-38-1
• Molecular Formula: C17H30N8O9
• Molecular Weight: 490.47
• Mol File: 99131-38-1.mol

Chemical Properties

• Appearance: /
• Density: 1.66±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 2.99±0.10(Predicted)
• CAS DataBase Reference: GRDGS(CAS DataBase Reference)
• NIST Chemistry Reference: GRDGS(99131-38-1)
• EPA Substance Registry System: GRDGS(99131-38-1)

Safety Data

• Hazardous Substances Data: 99131-38-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
GRDGS is used as an anticancer agent for its ability to inhibit the growth of cancer cells, offering a potential therapeutic approach in oncology.
Used in Tissue Repair and Regeneration:
GRDGS is used as a regenerative agent for its capacity to promote the repair and regeneration of damaged tissues, making it beneficial for wound healing and tissue recovery.
Used in Inflammation Management:
GRDGS is used as an anti-inflammatory agent for its potential to reduce inflammation, which can be advantageous in treating various inflammatory conditions.
Used in Tissue Engineering:
GRDGS is used as a component in tissue engineering for its role in enhancing the growth and development of tissues, contributing to the advancement of regenerative medicine.
Used in Regenerative Medicine:
GRDGS is used as a therapeutic agent in regenerative medicine for its potential to support the body's natural healing processes and promote tissue repair.

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 136083-57-3 N-α-9-fluorenylmethoxycarbonyl-aspartic acid 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 91000-69-0 Fmoc-L-Arg-OH 

Relevant articles and documents

Peptide microarrays for the discovery of bioactive surfaces that guide cellular processes: A single step azide-alkyne click chemistry approach

Cell behavior in vivo is guided by a complex microenvironment containing many different molecules including extracellular matrix (ECM) proteins, growth factors, and proteoglycans. Controlling the interaction between these various components at the cell-material interface will be invaluable in developing new materials for biomedical devices and tissue engineering applications. We report a single step approach to forming mixed peptide conjugated self-assembled monolayers on gold using copper-catalyzed azide-alkyne cycloaddition chemistry to study the combinatorial effects of different peptide ligands on cellular processes. We synthesized ECM adhesion peptides (YIGSR, GRGDS), a bone morphogenetic protein 7 (BMP-7) derived peptide (KPSSAPTQLN), and a heparin binding peptide (KRSR), and arrayed them, alone and in combination, onto gold coated coverslips. SAMs were characterized by X-ray photoelectron spectroscopy (XPS) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, and arrayed peptide combinations were seen to differentially bind to adipose derived stem cells (ADSCs) and mouse embryonic fibroblasts (MEFs). We further investigated the osteogenesis of ADSCs on SAMs containing combinations of adhesion peptide and BMP-7 peptide in both standard culture and osteogenic differentiation media. We demonstrate enhanced expression of osteogenic markers Runx2 and osteopontin when ADSCs are adherent to BMP-7 derived peptide alone or in combination with ECM adhesion peptides. The platform presented here enables immobilization of multiple peptides in a single step using a commercially available microarray spotter which will prove useful in fabricating biomolecule interfaces for cell biology studies and biochemical assays. This journal is the Partner Organisations 2014.