99134-12-0

Basic information

• Product Name: N-(3-fluoropropyl)-N-normetazocine
• Synonyms: N-(3-fluoropropyl)-N-normetazocine
• CAS NO: 99134-12-0
• Molecular Formula: C17H24FNO
• Molecular Weight: 277.3769632
• Mol File: 99134-12-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 392.1°C at 760 mmHg
• Flash Point: 190.9°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: N-(3-fluoropropyl)-N-normetazocine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoropropyl)-N-normetazocine(99134-12-0)
• EPA Substance Registry System: N-(3-fluoropropyl)-N-normetazocine(99134-12-0)

Safety Data

• Hazardous Substances Data: 99134-12-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H24FNO/c1-12-16-10-13-4-5-14(20)11-15(13)17(12,2)6-9-19(16)8-3-7-18/h4-5,11-12,16,20H,3,6-10H2,1-2H3/t12?,16-,17-/m0/s1

Upstream product

• 352-91-0 1-Bromo-3-fluoropropane 
• 16603-67-1 (2R,6R,11R)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol 

Relevant articles and documents

Enantiomeric (-)-(1R,5R,9R) and (+)-(1S,5S,9S) heterocyclic N-substituted-normetazocines: Synthesis of potent and selective antinociceptives and opioid antagonists through N-substituent modification

A number of diverse N-substituted-N-normetazocine heterocycles ((-)-1R,5R,9R)- and (+)-(1S,5S,9S)-5,9-dimethyl-2′-hydroxy-2-substituted-6,7-benzomorphans) were synthesized and evaluated. Conversion of an antinociceptively inactive alcohol to an ether (-)-1R,5R,9R)-5,9-dimethyl-2′-hydroxy-2-(2-methoxyethyl)-6,7-benzomorph an ((-)-N-methoxyethylnormetazocine, 4), gave a compound that was 10 to 40 times more potent than morphine as an antinociceptive agent, but did not attenuate morphine withdrawal in monkeys. Other (-)-enantiomers also had potent antinociceptive activity and one, (-)-N-fluoropropylnormetazocine (9), was a potent opioid antagonist.