99179-22-3

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

Sulfonamides are a class of compounds known for their antimicrobial and antifungal properties.
3. Antimicrobial Properties

Explanation

The compound has the potential to inhibit the growth of microorganisms, making it useful in treating bacterial infections.
4. Antifungal Properties

Explanation

The compound has been investigated for its potential to inhibit the growth of fungi, particularly pathogenic strains.
5. Carbonic Anhydrase Inhibition

Explanation

The compound has potential pharmaceutical applications as an inhibitor of carbonic anhydrase enzymes, which are involved in various physiological processes.
6. Pharmaceutical Applications

Explanation

Due to its antimicrobial, antifungal, and carbonic anhydrase inhibition properties, the compound may be used in the development of new drugs for various medical conditions.
7. Treatment of Neurological Disorders

Explanation

The compound is being studied for its potential use in treating neurological disorders, possibly due to its ability to inhibit certain enzymes or affect specific pathways in the nervous system.
8. Treatment of Cancer

Explanation

The compound is also being investigated for its potential use in cancer treatment, possibly through its interaction with specific cellular targets or pathways involved in cancer progression.

Explanation

The compound's structure is characterized by a thiadiazole ring fused to a sulfonamide group, with an additional (4-methylphenyl)sulfonyl group attached to the amino group.
10. Chemical Stability

Explanation

As a member of the sulfonamide class, the compound is likely to have a certain level of chemical stability, which is important for its potential pharmaceutical applications.

Class

Sulfonamide

Structure

1,3,4-Thiadiazole-2-sulfonamide, 5-[[(4-methylphenyl)sulfonyl]amino]-

Upstream product

• 14949-00-9 5-amino-1, 3, 4-thiadiazole-2-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1311297-37-6 C₁₂H₁₆N₄O₄S₃ 
• 1311297-38-7 C₂₉H₂₆N₄O₄S₃ 

Relevant academic research and scientific papers

Synthesis and evaluation of new carbonic anhydrase inhibitors

A series of new sulfamide derivatives have been synthesized, their structures were confirmed by 1H NMR and ESI-MS. Some target compounds were assessed by the tool of Dock6, and inhibition effects of all the new compounds on carbonic anhydrase II have been investigated. In addition, some compounds have been investigated for their antihypoxic effects in mice. Results indicated that nine target compounds exhibit as effectively as acetazolamide and 10 compounds have more potent inhibition effects on carbonic anhydrase II than acetazolamide. Three of them (I-8, I-18 and I′-3) can prolong markedly the survival time of mice in hypoxia, which are worth carrying out further studies.

Carbonic anhydrase inhibitors - Part 29: Interaction of isozymes I, II and IV with benzolamide-like derivatives

Reaction of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-imino-4- methyl-2-sulfonamido-δ2-1,3,4-thiadiazoline with sulfonyl halides/sulfonic acid anhydrides afforded benzolamide-like derivatives possessing strong inhibitory effects towards three isozymes of carbonic anhydrase (CA), CA I, II anal IV. Some of the compounds were designed in such a way to possess good leaving groups (such as nitro-; 2,4,6-triphenyl-pyridinium, etc.) for aromatic nucleophilic substitution reactions with fluoride, in order to introdUCe positron-emitting isotopes in their molecule, such as 18F. Reactions done initially with the stable isotope of fluorine were not very effective, as the yields in the desired fluoro-derivatives were low, and a complex reaction mixture was obtained. By using this type of approach, and optimizing the synthetic procedure, CA inhibitors for positron emission tomography (PET) applications might be obtained (in the case utilizing a carrier, which is the non-radioactive derivative itself, since the affinities of such derivatives for the receptor are in the nanomolar range). Further improving of such synthetic procedures might lead to better yields and the respective CompOUnds should be used as selective ligands (also in carrier- free systems) in assessing the role of membrane bound CA isozymes or for new diagnostic tools based on PET.

Treatment of chronic inflammatory joint disease with arylsulfonamides

A method of treating chronic inflammatory joint disease with arylsulfonamides of the formula: wherein R1 and R2 are selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, phenyl, loweralkylphenyl, 2 or 3 pyrrolidinyl, 2 or 3-(N-loweralkylpyrrolidinyl, or R1 and R2 taken together may form pyrrolidinyl or piperidinyl heterocyclic amino radicals and Z is an aryl group selected from substituted or unsubstituted tetrazole, 1,3,4-thiadiazole, 1,2,4-triazole, benzothiazole, benzimidazole, imidazole, pyridyl, 4,6-dimethyl pyrimidine, benzene or naphthalene is disclosed.