99186-25-1

Basic information

• Product Name: (2-PHENYLETHYL)THIO]ACETIC ACID
• Synonyms: Acetic acid,(phenethylthio)- (6CI); Acetic acid, [(2-phenylethyl)thio]- (9CI); NSC 158362;S-Phenylethylthioglycolic acid
• CAS NO: 99186-25-1
• Molecular Formula: C₁₀H₁₂O₂S
• Molecular Weight: 196.26608
• Mol File: 99186-25-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-PHENYLETHYL)THIO]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-PHENYLETHYL)THIO]ACETIC ACID(99186-25-1)
• EPA Substance Registry System: (2-PHENYLETHYL)THIO]ACETIC ACID(99186-25-1)

Safety Data

• Hazardous Substances Data: 99186-25-1(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 68-11-1 mercaptoacetic acid 
• 622-24-2 2-phenylethyl chloride 
• 4410-99-5 2-mercaptophenylethane 
• 79-11-8 chloroacetic acid 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 50354-52-4 methyl 2-(phenylethylthio)acetate 
• 99070-67-4 phenethylmercapto-acetyl chloride 
• 860540-31-4 (2-phenyl)ethylsulfinylacetic acid 
• 137524-38-0 2-(phenylethylsulfonyl)acetic acid 
• 298-12-4 Glyoxilic acid 
• 1609008-00-5 E-acetic acid 2-acetoxy-4-[2-(2-phenylethanesulfinyl)vinyl]-phenyl ester 
• 1609007-92-2 E-acetic acid 2-acetoxy-4-[2-(2-phenylethanesulfonyl)vinyl]phenyl ester 
• 91767-53-2 ethyl 2-chloro-2-(2-phenylethylthio)acetate 
• 91555-77-0 ethyl (2-phenylethylsulfonyl)acetate 
• 137524-71-1 1-Nitro-4-[(E)-2-(2-phenyl-ethanesulfonyl)-vinyl]-benzene 
• 138760-05-1 1-Nitro-2-[(E)-2-(2-phenyl-ethanesulfonyl)-vinyl]-benzene 
• 137524-73-3 1,3-Dichloro-2-[(E)-2-(2-phenyl-ethanesulfonyl)-vinyl]-benzene 
• 137524-72-2 2,4-Dichloro-1-[(E)-2-(2-phenyl-ethanesulfonyl)-vinyl]-benzene 
• 137524-74-4 1,2-Dichloro-4-[(E)-2-(2-phenyl-ethanesulfonyl)-vinyl]-benzene 

Relevant articles and documents

Photoinitiated Thiol-Ene “Click” Reaction: An Organocatalytic Alternative

The thiol-ene coupling (TEC) reaction has attracted a lot of scientific attention during the last years, particularly in the fields of polymers, materials and more recently in drug design. The combination of organocatalysis and photocatalysis has enabled the development of an efficient synergistic protocol for the addition of various thiols to a plethora of olefins. Utilizing phenylglyoxylic acid as the catalyst-initiator and common household bulbs as the light source, we report an organocatalytic photoinitiated TEC reaction showing exceptional tolerance in the presence of various functionalities, untangling previously unsolved problems. (Figure presented.).

Design, synthesis, and biological evaluation of (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents

Novel (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides were designed and synthesized as new analogues of 1, which showed interesting multifunctional neuroprotective effects, including antioxidative and antineuroinflammatory properties. Specifically, target compounds display excellent potency in scavenging reactive free radicals and demonstrate potent effects against various kinds of toxicities, including H2O2, 6-hydroxydopamine, and lipopolysaccharide in different types of neuronal cells. The antioxidative properties of the target compounds are more potent than that of 1, and the antineuroinflammatory properties are less strong than that of 1. According to the parallel artificial membrane permeation assay for the blood-brain barrier, target compounds possess greater blood-brain barrier (BBB) permeability than 1. In short, due to improvement of the antioxidative effect, stability, and BBB permeability, (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides can thus be considered as potential multifunctional neuroprotective agents and serve as new lead candidates in the treatment of neurodegenerative diseases.

MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES

Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

Macrolides with antibacterial activity

The invention provides new macrolides antibiotics of formula (I) with improved biological properties and improved stability formula (I): wherein R1 is hydrogen, cyano, —S(L)mR2, —S(O)(L)mR2, or —S(O)

A novel and convenient synthesis of E,E-bis(styryl)sulfones and E,E-1,4-diaryl-1,3-butadienes

The condensation of 2-phenylethanesulfonylacetic acid (4) with araldehydes (5) in presence of a base gave E-styryl-2-phenylethyl sulfones (6) which on dehydrogenation with DDQ (7) yielded E,E-bis-(styryl)sulfones (8). The 8 on treatment with dichlorotris(triphenyl-phosphine)ruthehium(II) catalyst resulted 1,4-diaryl-1,3-butadienes (9). The configurations of 6, 8 and 9 have been determined based on IR and 1H NMR spectral data.