99196-57-3

Upstream product

• 111-83-1 1-bromo-octane 
• 3943-97-3 methyl 4-hydroxycinnamate 
• 629-27-6 1-Iodooctane 

Downstream Products

• 99196-58-4 (2E)-3-[4-(octyloxy)phenyl]-2-propenoic acid 
• 77251-81-1 trans-octyloxycinnamoyl chloride 
• 492452-76-3 N,N-bis(2-hydroxyethyl)-3-(4-octyloxyphenyl)-2-propenamide 
• 110683-51-7 (E)-3-(4-Octyloxy-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide 

Relevant academic research and scientific papers

Cinnamic acid derived oxazolinium ions as novel cytotoxic agents.

Substituted cinnamoyl chlorides, 11, were converted into (2-hydroxyethyl)-oxazolinium chlorides 14, N,N-bis-(2-chloroethyl)amides 16 and (2-chloroethyl)-oxazolinium chlorides 17. Although derivatives 14 which possess electron-donating substituents (Me or MeO) were more potent than those substituted by electron-withdrawing groups (NO(2), Cl or CF(3)), the difference in cytotoxic actin was not significant. Modification of the lipophilic character in a series of alkoxy-substituted derivatives 14 led to more active compounds, where 14t that possesses a 4-octyloxy-phenyl-substituent was the most potent and displayed cytotoxic activity in the microM range. It is assumed that the oxazolinium salts act as alkylating agents, and undergo nucleophilic attack on the methylene adjacent to the ring oxygen where the oxazolinium ring parallels the aziridinium ring intermediate found in classical alkylating agents.

Phosphoric diesters which absorb UV rays, method of preparing the same, and cosmetic compositions containing the same

Phosphoric diesters having formula (1): STR1 wherein R1 is an acyl group having at least one phenyl group; R2 is a C2-12 linear or branched alkylene group which may optionally be inserted with an oxygen atom between carbon atoms thereof; L is a C2-40 linear or branched alkyl group which may optionally be inserted with an oxygen atom between carbon atoms thereof or the group R1 -O-R2 ; M is a hydrogen atom, an alkali metal ion, a metal ion of di- or higher valence, an ammonium group, an alkanolammonium group having 2 to 14 carbon atoms, C1-14 alkylammonium group; and n is the valence of M are useful UV absorbing compounds. The phosphoric diesters remain on the skin for long periods of time and exhibit lasting UV shielding effects. The compounds and the cosmetic compositions containing the compounds are very safe to the skin.

Non-chiral compounds exhibiting alternating tilt smectic phases

In this article we present an investigation of the liquid crystal properties of non-chiral and racemic branched alkyl chain (swallow-tailed) molecules and some chiral analogues based on a cinnamic acid core group. It was found in these systems that increasing the extent of the branching of the terminal alkyl chain increased the incidence of alternating tilt smectic phases, whereas smectic Cα and smectic Cγ phases were suppressed. X-ray studies of the effect on the layer spacing in the smectic A phase of increasing the long alkyl branch of one series of compounds are included. Results of polarisation studies on some chiral analogues are also reported.