99198-79-5

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 71879-55-5 ethyl 3-(piperid-4-yl)propionate 
• 99197-90-7 ethyl 4-(1-benzyloxycarbonyl-4-piperidyl)-2-oxobutyrate 
• 123293-78-7 ethyl 3-(4-pyridinyl)-(2E)-propenoate 
• 99197-86-1 ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate 
• 99198-77-3 ethyl 4-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxybutyrate 
• 91370-63-7 ethyl 4-(piperidin-4-yl)butyrate 
• 501-53-1 benzyl chloroformate 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 623-51-8 ethyl 2-sulfanylacetate 
• 19493-09-5 Methylenetriphenylphosphorane 

Downstream Products

• 99198-55-7 ethyl 5-(1-benzyloxycarbonyl-4-piperidyl)-2-oxovalerate 
• 566905-88-2 benzyl 4-(4-hydroxybutyl)piperidine-N-carboxylate 
• 566905-90-6 benzyl 4-(4-bromobutyl)piperidine-N-carboxylate 
• 566905-94-0 benzyl 4-{4-[bis(tert-butoxycarbonyl)amino]butyl}piperidine-N-carboxylate 
• 566906-02-3 2-(4-{4-[bis(tert-butoxycarbonyl)amino]butyl}piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate 
• 99198-57-9 4-[(S)-4-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-ethoxycarbonyl-butyl]-piperidine-1-carboxylic acid benzyl ester 
• 99198-56-8 benzyl 3(S)-[4-(1-benzyloxycarbonyl-4-piperidyl)-1(R)-ethoxycarbonylbutyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate 
• 100303-26-2 4-[(S)-4-((R)-5-tert-Butoxycarbonylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-ethoxycarbonyl-butyl]-piperidine-1-carboxylic acid benzyl ester 
• 100303-25-1 4-[(R)-4-((R)-5-tert-Butoxycarbonylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-ethoxycarbonyl-butyl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

Cascade reactions are green and powerful transformations for building multiple carbon-carbon bonds in one step. Through a relay olefination and radical addition process, we were able to develop the cascade Wittig/hydroalkylation reactions induced by visible light. This metal-free radical approach features mild conditions, robustness, and excellent functionality compatibility. It allows access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method is demonstrated by a two-step synthesis ofindolizidine 209D.

Condensed seven-membered ring compounds, their production and use

Novel condensed seven-membered ring compounds of the formula: STR1 [wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R3 and R5 are independently hydrogen, lower alkyl or aralkyl; R4 is hydrogen or lower alkyl; R6 is a condensed or non-condensed hetero-alicyclic containing at least one atom of N, O and S as a ring-forming atom which may be substituted; A is an alkylene chain; n is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases, such as hypertension, cardiopathy and cerebral apoploxy.

3-Amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives

Novel 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives of the formula STR1 [wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R3 is hydrogen, optionally substituted lower alkyl or optionally substituted aralkyl; R4 is hydrogen, optionally substituted alkyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl; Y is a carboxyl group which may be esterified or amidated; m is 1 or 2] and salts thereof. These compounds and salts thereof exhibits inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases (e.g. hypertension, cardiopathy, cerebral apoploxy).