99210-94-3

Upstream product

• 88635-97-6 (4R,5S,2'S)-3-(2'-benzoylpropanoyl)-4-methyl-5-phenyl-2-oxazolidinone 
• 77877-20-4 (4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one 
• 88635-97-6 2-Methyl-1-((R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione 

Downstream Products

• 76549-03-6 methyl (2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoate 
• 14366-89-3 methyl 3-hydroxy-2-methyl-3-phenylpropanoate 

Relevant academic research and scientific papers

Erythro-Directive Reduction of α-Substituted Alkanones by Means of Hydrosilanes in Acidic Media

Hydrosilane reduced α-oxy and α-amino ketones and β-keto acid derivatives in trifluoroacetic acid to afford the corresponding erythro alcohols with high diastereoselectivity.The reaction proceeded without racemization at the carbon α to the carbonyl group.The erythro-directive reduction was explained in terms of the proton-bridged Cram cyclic model and successfully applied to the synthesis of physiologically important amino alcohols such as l-ephedrine, l-methoxamine, and erythro-2-methyl-3-piperidino-1-phenylpropanol.