99236-17-6

Usage

Uses

Used in Pharmaceutical Research:
Ethanone, 1-(4-chlorophenyl)-2-[(4-methylphenyl)thio]is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique molecular structure allows for the development of new medications with potential therapeutic applications.
Used in Medicinal Chemistry:
Ethanone, 1-(4-chlorophenyl)-2-[(4-methylphenyl)thio]is employed as a valuable tool in medicinal chemistry for exploring its biological activity. Its potential to exhibit therapeutic effects makes it a promising candidate for further research and development in the field of drug discovery.
Used in Agrochemical Development:
Ethanone, 1-(4-chlorophenyl)-2-[(4-methylphenyl)thio]is also utilized in the development of agrochemicals. Its unique properties and potential applications in this field contribute to the creation of new products for agricultural use.

Upstream product

• 103-19-5 di(p-tolyl) disulfide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 18276-77-2 Phosphorsaeure-diethylester-<1-(4-chlor-phenyl)-vinylester> 
• 106-45-6 para-thiocresol 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 103-19-5 di(p-tolyl) disulfide 
• 24314-35-0 1,4-bis(4-chlorophenyl)butane-1,4-dione 
• 99-91-2 para-chloroacetophenone 
• 1235497-47-8 4,6-bis(4-chlorophenyl)-2-ethoxy-5-[(4-methylphenyl)sulfanyl]nicotinonitrile 
• 1235497-50-3 6-(4-chlorophenyl)-2-ethoxy-4-(4-methoxyphenyl)-5-[(4-methylphenyl)sulfanyl]nicotinonitrile 
• 1235497-45-6 6-(4-chlorophenyl)-4-[4-(dimethylamino)phenyl]-2-ethoxy-5-[(4-methylphenyl)sulfanyl]nicotinonitrile 
• 61820-94-8 1-(4-chlorophenyl)-2-tosylethanone 
• 1586031-09-5 C₁₇H₁₇ClO₂S 
• 1260255-28-4 1-(4-chlorophenyl)-2-[(4-methylphenyl)sulfanyl]-1-ethanone N-(Z)-1-(4-chlorophenyl)-2-[(4-methylphenyl)sulfanyl]ethylidenehydrazone 

Relevant academic research and scientific papers

Electrocatalytic Synthesis of gem -Bisarylthio Enamines and α-Phenylthio Ketones via a Radical Process under Mild Conditions

The novel method for the synthesis of gem -bisarylthio enamines and α-phenylthio ketones was developed via the coupling of α-substituted vinyl azides with thiols in the presence of tetrabutylammonium iodide (TBAI) as a redox catalyst and electrolyte at ro

Electrophilic Chlorine from Chlorosulfonium Salts: A Highly Chemoselective Reduction of Sulfoxides

Herein, we describe a selective late-stage deoxygenation of sulfoxides based on a novel application of chlorosulfonium salts and demonstrate a new process using these species generated in situ from sulfoxides as the source of electrophilic chlorine. The use of highly nucleophilic 1,3,5-trimethoxybenzene (TMB) as the reducing agent is described for the first time and applied in the deoxygenation of simple and functionalized sulfoxides. The method is easy to handle, economic, suitable for gram-scale operations, and readily applied for poly-functionalized molecules, as demonstrated with more than 45 examples, including commercial medicines and analogues. We also report the results of competition experiments that define the more reactive sulfoxide and we present a mechanistic proposal based on substrate and product observations.

Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of β-Keto Sulfides and Sulfones

Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of β-keto sulfides and β-keto sulfones. The transformation, mediated by O2, proceeds smoothly in water and without any catalyst. Prominent advantages of this method include mild reaction conditions, purification simplicity, and gram-scale synthesis, underlining the practical utility of this methodology.

Dynamic covalent chemistry of disulfides offers a highly efficient synthesis of diverse benzofused nitrogen-sulfur heterocycles in one pot

The thiol-disulfide dynamic interchange reaction mediated by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) was extensively studied. By this synthetic method sulfides can be prepared successfully within seconds in high yields at room temperature from stable and readily available disulfides and an alkylating agent. The method was further demonstrated to efficiently produce benzofused nitrogen-sulfur heterocycles with high skeletal diversity in a one-pot process.

Selective one-pot multicomponent synthesis and anti-tubercular evaluation of 5-(aryl/cyclohexylsulfanyl)-2-alkoxy-4,6-diarylnicotinonitriles

A new set of highly substituted pyridine derivatives has been synthesized by a product selective four component reaction of aryl aldehyde, malononitrile and 2-aryl/cyclohexylsulfanyl-1-aryl-1-ethanones in presence of sodium hydroxide in methyl/ethyl alcoh

Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity

Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the forma

Photoreactions of β-Ketosulphides: Aryl and Benzyl Phenacyl Sulphides and Related Compounds

Photoreactions of aryl phenacyl sulphides were studied, particularly in regard to substituent and solvent effects.In general, aryl phenacyl sulphides Ar1SCH2COAr2 1 = p-tolyl, Ar2 = p-X-C6H4 (X = H, Cl, OH, OMe, and Ph), 2-thienyl, and 2-furyl; Ar1 = 2,4,6-trimethylphenyl, Ar2 = Ph and p-HOC6H4; Ar1 = 2-benzthiazolyl, Ar2 = Ph> underwent photochemical cleavage to disulphides (Ar1S)2 and ketones Ar2COMe.In a few cases a diketone (Ar2COCH2)2 was the only, or major, carbonyl photoproduct.Similar photochemical behaviour was shown by ketosulphides p-Me-C6H4SCH(R)COPh (R = PhCH2, PhCOCH2, and p-Me-C6H4S) and related acetophenone derivatives PhCOCH2SR (R = COPh, SO3Na, and SCH2COPh).In a few instances, from p-Me-C6H4SCH2COAr (Ar = Ph, p-Cl-C6H4, and p-Ph-C6H4), a minor photoproduct was a 2-aryl-5-methylbenzothiophen.Benzyl phenacyl sulphides p-X-C6H4COCH2SCH2Ph (X = OH and OMe) also underwent photo-cleavage to give dibenzyl disulphide and a ketone.Free-radical cleavage products ArCOCH2(.) (Ar = Ph and p-MeO-C6H4) and p-Me-C6H4S(.) were trapped as adducts p-Me-C6H4SC(Ph)2CH2CH2COAr when irradiation of the ketosulphide was carried out in the presence of 1,1-diphenylethylene. 2,5-Diphenylfuran was formed photochemically from 1,4-diphenylbutane-1,4-dione on irradiation in methanol.