99254-95-2Relevant academic research and scientific papers
1,2-1,4 addition reaction sequence leading to disubstituted acelylenes
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, (2008/06/13)
A method for synthesizing a tri-substituted phenyl compound (I) by using a 1,2-addition followed by a 1,4-addition to 1,4-benzoquinone (II): STR1 wherein X is hydroxy, alkoxy or alkanoyloxy, Ar1 is an organic group and R is an unsubstituted or
2-Ethynylbenzenealkanamines. A new class of calcium entry blockers
Carson,Almond,Brannan,Carmosin,Flaim,Gill,Gleason,Keely,Ludovici,Pitis,Rebarchak,Villani
, p. 630 - 636 (2007/10/02)
A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.
