99255-22-8Relevant articles and documents
Gold catalysis: Synthesis of 3-acylindenes from 2-alkynylaryl epoxides
Hashmi, A. Stephen K.,Buehrle, Miriam,Salathe, Ralph,Bats, Jan W.
supporting information; experimental part, p. 2059 - 2064 (2009/08/07)
A series of 2-alkynylaryl epoxides were prepared by a sequence of Sonogashira coupling, Wittig olefination and epoxidation or a Darzens' glycid ester synthesis. The conversion of these substrates with gold(I) catalysts furnished 3-acylindenes and, in occa
Methods for the treatment of hypertension
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, (2008/06/13)
Acetylene compounds of the formula (I): STR1 wherein Y, R1, R2, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihyperte
2-Ethynylbenzenealkanamines. A new class of calcium entry blockers
Carson,Almond,Brannan,Carmosin,Flaim,Gill,Gleason,Keely,Ludovici,Pitis,Rebarchak,Villani
, p. 630 - 636 (2007/10/02)
A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.
Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
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, (2008/06/13)
Acetylenes of the formula (I): STR1 wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.
